Applications of global sensitivity analysis to the optimization of a dermal PBPK model of bromochloromethane

DOI10.35834/2021/3302137zbMATH Open1486.92070OpenAlexW3215343198MaRDI QIDQ2116682FDOQ2116682

John W. Kenney, Jessica McEwain, Megan E. Sawyer

Publication date: 18 March 2022

Published in: Missouri Journal of Mathematical Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.35834/2021/3302137

zbMATH Keywords

optimizationsensitivity analysisMorris methodPBPK modeling

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Uses Software

• SAFE Toolbox

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