Applications of global sensitivity analysis to the optimization of a dermal PBPK model of bromochloromethane

DOI10.35834/2021/3302137MaRDI QIDQ2116682zbMATH OpenOpenAlexFDO

Authors Megan E. Sawyer, Jessica McEwain, John W. Kenney

Publication date 18 March 2022

Published in Missouri Journal of Mathematical Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.35834/2021/3302137

zbMATH Keywords

optimizationsensitivity analysisMorris methodPBPK modeling

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans
• Multiscale Global Sensitivity Analysis for Stochastic Chemical Systems
• Sensitivity analysis and model optimization for reaction-diffusion systems
• Insights of global sensitivity analysis in biological models with dependent parameters
• A tutorial on Sobol' global sensitivity analysis applied to biological models
• Computation and analysis of time-dependent sensitivities in generalized mass action systems
• GLOBAL SENSITIVITY ANALYSIS: AN EFFICIENT NUMERICAL METHOD FOR APPROXIMATING THE TOTAL SENSITIVITY INDEX
• Multi-method global sensitivity analysis of mathematical models
• A practical global sensitivity analysis methodology for multi-physics applications

Cited in

(5)

• Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model
• An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans
• Application of a stochastic model to estimate children's short-term residential exposure to lead
• Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs
• Local identifiability analysis, parameter subset selection and verification for a minimal brain PBPK model

Describes a project that uses

Uses Software

• SAFE Toolbox

This page was built for publication: Applications of global sensitivity analysis to the optimization of a dermal PBPK model of bromochloromethane

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2116682)