Machine learning for mathematical models of HCV kinetics during antiviral therapy

DOI10.1016/J.MBS.2021.108756MaRDI QIDQ2118485zbMATH OpenOpenAlexFDO

Authors Alexander Churkin, Stephanie Kriss, Asher Uziel, Ashish Goyal, Rami Zakh, Scott J. Cotler, Ohad Etzion, Amir Shlomai, Horacio G. Rotstein, Harel Dahari, Danny Barash

Publication date 22 March 2022

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2021.108756

zbMATH Keywords

direct-acting antiviralshepatitis C virusmachine learningmathematical modelingviral dynamics

Mathematics Subject Classification ID

Artificial neural networks and deep learning (68T07) Medical epidemiology (92C60)

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Cites work

• A method for the solution of certain non-linear problems in least squares
• A parameter estimation method for multiscale models of hepatitis C virus dynamics
• An Algorithm for Least-Squares Estimation of Nonlinear Parameters
• HIV-1 infection and low steady state viral loads
• scientific article; zbMATH DE number 1392848 (Why is no real title available?)
• Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy
• Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity
• Nonlinear diffusion filtering on extended neighborhood
• Numerical schemes for solving and optimizing multiscale models with age of hepatitis C virus dynamics
• On identifiability of nonlinear ODE models and applications in viral dynamics
• Random forests

Cited in

(5)

• Using machine learning algorithms to predict hepatitis B surface antigen seroclearance
• Combining mathematical modeling and deep learning to make rapid and explainable predictions of the patient-specific response to anticoagulant therapy under venous flow
• Towards prediction of HCV therapy efficiency
• Penalized trinomial logit models distinguish clinical stages in patients with hepatitis
• Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis

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