Machine learning for mathematical models of HCV kinetics during antiviral therapy

DOI10.1016/J.MBS.2021.108756zbMATH Open1486.92107OpenAlexW4200212321MaRDI QIDQ2118485FDOQ2118485

Authors: Alexander Churkin, Stephanie Kriss, Asher Uziel, Ashish Goyal, Rami Zakh, Scott J. Cotler, Ohad Etzion, Amir Shlomai, Horacio G. Rotstein, Harel Dahari, Danny Barash 

Publication date: 22 March 2022

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2021.108756

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zbMATH Keywords

machine learningmathematical modelingviral dynamicshepatitis C virusdirect-acting antivirals

Mathematics Subject Classification ID

Medical epidemiology (92C60) Artificial neural networks and deep learning (68T07)

Cites Work

• Random forests
• An Algorithm for Least-Squares Estimation of Nonlinear Parameters
• A method for the solution of certain non-linear problems in least squares
• On identifiability of nonlinear ODE models and applications in viral dynamics
• HIV-1 infection and low steady state viral loads
• Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity
• Title not available (Why is that?)
• A parameter estimation method for multiscale models of hepatitis C virus dynamics
• Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy
• Nonlinear diffusion filtering on extended neighborhood
• Numerical schemes for solving and optimizing multiscale models with age of hepatitis C virus dynamics

Cited In (5)

• Using machine learning algorithms to predict hepatitis B surface antigen seroclearance
• Towards prediction of HCV therapy efficiency
• Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis
• Penalized trinomial logit models distinguish clinical stages in patients with hepatitis
• Combining mathematical modeling and deep learning to make rapid and explainable predictions of the patient-specific response to anticoagulant therapy under venous flow

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