Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin

DOI10.1016/J.MBS.2013.07.005MaRDI QIDQ2437016zbMATH OpenOpenAlexWikidataFDO

Authors Sandip Banerjee, Ram Keval, Sunita Gakkhar

Publication date 27 February 2014

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1105.3669

zbMATH Keywords

target cellsinterferonribavirinhepatitis C virus (HCV)infected cellsinfectious virionsnoninfectious virions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60) Stability of solutions to ordinary differential equations (34D20)

Abstract: A mathematical modeling of Hepatitis C Virus (HCV) dynamics has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions. The model takes into consideration the addition of ribavirin to interferon therapy and explains the dynamics regarding biphasic and triphasic decline of viral load in the model. A critical drug efficiency parameter has been defined and it is shown that for efficiencies above this critical value, HCV is eradicated whereas for efficiencies lower this critical value, a new steady state for infectious virions is reached, which is lower than the previous steady state.

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Cited in

(22)

• Dynamical analysis of a class of hepatitis C virus infection models with application of optimal control
• A theoretical model of chronic hepatitis B virus with suboptimal adherence and drug resistance
• Hopf bifurcation and stability switches induced by humoral immune delay in hepatitis C
• Dynamics of hepatitis C virus infection: mathematical modeling and parameter estimation
• Modeling the effect of non-cytolytic immune response on viral infection dynamics in the presence of humoral immunity
• The influence of vaccination on the control of JE with a standard incidence rate of mosquitoes, pigs and humans
• Stochastic analysis of in-host HCV dynamics through budding and bursting process
• Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis
• Towards prediction of HCV therapy efficiency
• Influence of intracellular delay on the dynamics of Hepatitis C virus
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• Modelling hepatotoxicity and antiretroviral therapeutic effect in HIV/HBV coinfection
• Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy
• Machine learning for mathematical models of HCV kinetics during antiviral therapy
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• Observer‐based controller for treatment of hepatitis C infection using fractional order model
• Modeling of viral dynamics after liver transplantation in patients with chronic hepatitis B and D
• Chronic hepatitis B infection and HBV DNA-containing capsids: modeling and analysis

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