Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin

DOI10.1016/J.MBS.2013.07.005zbMATH Open1308.92062arXiv1105.3669OpenAlexW2093398178WikidataQ42253516 ScholiaQ42253516MaRDI QIDQ2437016FDOQ2437016

Authors: Sandip Banerjee, Ram Keval, Sunita Gakkhar 

Publication date: 27 February 2014

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: A mathematical modeling of Hepatitis C Virus (HCV) dynamics has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions. The model takes into consideration the addition of ribavirin to interferon therapy and explains the dynamics regarding biphasic and triphasic decline of viral load in the model. A critical drug efficiency parameter has been defined and it is shown that for efficiencies above this critical value, HCV is eradicated whereas for efficiencies lower this critical value, a new steady state for infectious virions is reached, which is lower than the previous steady state.

Full work available at URL: https://arxiv.org/abs/1105.3669

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zbMATH Keywords

target cellsinterferonribavirinhepatitis C virus (HCV)infected cellsinfectious virionsnoninfectious virions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60) Stability of solutions to ordinary differential equations (34D20)

Cites Work

• HIV-1 infection and low steady state viral loads
• Compound matrices and ordinary differential equations
• A Geometric Approach to Global-Stability Problems
• Uniformly Persistent Systems
• Additive compound matrices and an inequality for eigenvalues of symmetric stochastic matrices
• Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy
• Evaluating treatment of hepatitis C for hemolytic anemia management
• OPTIMALLY CONTROLLED TREATMENT STRATEGY USING INTERFERON AND RIBAVIRIN FOR HEPATITIS C

Cited In (16)

• Hopf bifurcation and stability switches induced by humoral immune delay in hepatitis C
• Evaluating treatment of hepatitis C for hemolytic anemia management
• Global analysis of a mathematical model for hepatitis C considering the host immune system
• Modeling the effect of non-cytolytic immune response on viral infection dynamics in the presence of humoral immunity
• Threshold dynamics of HCV model with cell-to-cell transmission and a non-cytolytic cure in the presence of humoral immunity
• Some sufficient conditions for global asymptotic stability of a hepatitis C virus mathematical model considering host immune system
• Towards prediction of HCV therapy efficiency
• Observer‐based controller for treatment of hepatitis C infection using fractional order model
• Chronic hepatitis B infection and HBV DNA-containing capsids: modeling and analysis
• Dynamical analysis of a class of hepatitis C virus infection models with application of optimal control
• Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis
• The influence of vaccination on the control of JE with a standard incidence rate of mosquitoes, pigs and humans
• Influence of intracellular delay on the dynamics of Hepatitis C virus
• Stochastic analysis of in-host HCV dynamics through budding and bursting process
• Modelling hepatotoxicity and antiretroviral therapeutic effect in HIV/HBV coinfection
• Machine learning for mathematical models of HCV kinetics during antiviral therapy

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