Optimal control of the SIR model with constrained policy, with an application to COVID-19

DOI10.1016/J.MBS.2021.108758MaRDI QIDQ2118494zbMATH OpenOpenAlexFDO

Authors Yujia Ding, Henry Schellhorn

Publication date 22 March 2022

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2105.08848

zbMATH Keywords

COVID-19epidemiologypopulation controlSIR modelstochastic optimal control

Mathematics Subject Classification ID

Epidemiology (92D30) Optimal stochastic control (93E20)

Abstract: This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First, we prove the existence of a solution to the model. Second, our interpretation of the control is more realistic: while in Gatto and Schellhorn the control $alpha$ is the proportion of the population that takes a basic dose of treatment, so that $alpha>1$ occurs only if some patients take more than a basic dose, in our paper, $alpha$ is constrained between zero and one, and represents thus the proportion of the population undergoing treatment. Third, we provide a complete solution for the moderate infection regime (with constant treatment). Finally, we give a thorough interpretation of the control in the moderate infection regime, while Gatto and Schellhorn focussed on the interpretation of the low infection regime. Finally, we compare the efficiency of our control to curb the COVID-19 epidemic to other types of control.

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Cited in

(15)

• Robust optimal control of compartmental models in epidemiology: application to the COVID-19 pandemic
• Optimal control of the SIR model in the presence of transmission and treatment uncertainty
• Mortality containment vs. economics opening: optimal policies in a SEIARD model
• Revisiting SIR in the age of COVID-19: explicit solutions and control problems
• scientific article; zbMATH DE number 7668226 (Why is no real title available?)
• Optimal control strategy to control pandemic Covid-19 using MSI_LI_HR_V Model
• Interval nonlinear initial-valued problem using constraint intervals: theory and an application to the SARS-CoV-2 outbreak
• Feedback control of isolation and contact for SIQR epidemic model via strict Lyapunov function
• Optimal control problem of various epidemic models with uncertainty based on deep reinforcement learning
• Optimal control on a mathematical model of SIR and application to Covid-19
• Optimal policy for control of epidemics with constrained time intervals and region-based interactions
• Optimal control of an epidemiological Covid-19 model with state constraint
• Optimal control for an SIR model with limited hospitalised patients
• Fractional differential equations of a reaction-diffusion SIR model involving the Caputo-fractional time-derivative and a nonlinear diffusion operator
• The impact of hospital resources and environmental perturbations on the dynamics of a disease transmission model with density-dependent demographics

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