Tensor PDE model of biological network formation

DOI10.4310/CMS.2022.V20.N4.A10MaRDI QIDQ2129682zbMATH OpenOpenAlexWikidataFDO

Authors Jan Haškovec, Giulia Pilli, Peter Alexander Markowich

Publication date 22 April 2022

Published in Communications in Mathematical Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2111.03889

zbMATH Keywords

gradient flowcontinuum limitbiological transportation networkstensor PDE model

Mathematics Subject Classification ID

Systems biology, networks (92C42) Weak solutions to PDEs (35D30) Initial-boundary value problems for systems of nonlinear higher-order PDEs (35G61) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: We study an elliptic-parabolic system of partial differential equations describing formation of biological network structures. The model takes into consideration the evolution of the permeability tensor under the influence of a diffusion term, representing randomness in the material structure, a decay term describing metabolic cost and a pressure force. A Darcy's law type equation describes the pressure field. In the spatially two-dimensional setting, we present a constructive, formal derivation of the PDE system from the discrete network formation model in the refinement limit of a sequence of unstructured triangulations. Moreover, we show that the PDE system is a formal $L^2$-gradient flow of an energy functional with biological interpretation, and study its convexity properties. For the case when the energy functional is convex, we construct unique global weak solutions of the PDE system. Finally, we construct steady state solutions in one- and multi-dimensional settings and discuss their stability properties.

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Cited in

(15)

• Notes on a PDE system for biological network formation
• Network development in biological gels: role in lymphatic vessel development
• Asymmetry and condition number of an elliptic-parabolic system for biological network formation
• Mathematical Analysis of a PDE System for Biological Network Formation
• Implicit and semi-implicit numerical schemes for the gradient flow of the formation of biological transport networks
• Self-regulated biological transportation structures with general entropy dissipation: 2D case and leaf-shaped domain
• Numerical approach to centrality of optimal transportation networks
• Robust network formation with biological applications
• ODE- and PDE-based modeling of biological transportation networks
• Measure-based approach to mesoscopic modeling of optimal transportation networks
• Boundedness and long-time behavior in a parabolic-elliptic system arising from biological transport networks
• Emergence of biological transportation networks as a self-regulated process
• Rigorous continuum limit for the discrete network formation problem
• A modified and efficient phase field model for the biological transport network
• Regularity theorems for a biological network formulation model in two space dimensions

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