Tensor PDE model of biological network formation

DOI10.4310/CMS.2022.V20.N4.A10zbMATH Open1492.35365arXiv2111.03889OpenAlexW3212643599WikidataQ113691710 ScholiaQ113691710MaRDI QIDQ2129682FDOQ2129682

Peter Alexander Markowich, Giulia Pilli, Jan Haškovec

Publication date: 22 April 2022

Published in: Communications in Mathematical Sciences (Search for Journal in Brave)

Abstract: We study an elliptic-parabolic system of partial differential equations describing formation of biological network structures. The model takes into consideration the evolution of the permeability tensor under the influence of a diffusion term, representing randomness in the material structure, a decay term describing metabolic cost and a pressure force. A Darcy's law type equation describes the pressure field. In the spatially two-dimensional setting, we present a constructive, formal derivation of the PDE system from the discrete network formation model in the refinement limit of a sequence of unstructured triangulations. Moreover, we show that the PDE system is a formal $L^2$-gradient flow of an energy functional with biological interpretation, and study its convexity properties. For the case when the energy functional is convex, we construct unique global weak solutions of the PDE system. Finally, we construct steady state solutions in one- and multi-dimensional settings and discuss their stability properties.

Full work available at URL: https://arxiv.org/abs/2111.03889

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zbMATH Keywords

gradient flowcontinuum limitbiological transportation networkstensor PDE model

Mathematics Subject Classification ID

Systems biology, networks (92C42) Weak solutions to PDEs (35D30) Initial-boundary value problems for systems of nonlinear higher-order PDEs (35G61) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cited In (6)

• Network development in biological gels: role in lymphatic vessel development
• Mathematical Analysis of a PDE System for Biological Network Formation
• Robust network formation with biological applications
• Boundedness and long-time behavior in a parabolic-elliptic system arising from biological transport networks
• Emergence of biological transportation networks as a self-regulated process
• Regularity theorems for a biological network formulation model in two space dimensions

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