Hierarchical correction of p-values via an ultrametric tree running Ornstein-Uhlenbeck process

DOI10.1007/S00180-021-01148-6MaRDI QIDQ2155000zbMATH OpenOpenAlexFDO

Authors Antoine Bichat, Christophe Ambroise, Mahendra Mariadassou

Publication date 15 July 2022

Published in Computational Statistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2009.13335

zbMATH Keywords

Lassomultiple testingOrnstein-Uhlenbeck processdebiasingFDR controlmetagenomic

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Applications of statistics to biology and medical sciences; meta analysis (62P10) Ridge regression; shrinkage estimators (Lasso) (62J07) Paired and multiple comparisons; multiple testing (62J15)

Abstract: Statistical testing is classically used as an exploratory tool to search for association between a phenotype and many possible explanatory variables. This approach often leads to multiple testing under dependence. We assume a hierarchical structure between tests via an Ornstein-Uhlenbeck process on a tree. The process correlation structure is used for smoothing the p-values. We design a penalized estimation of the mean of the Ornstein-Uhlenbeck process for p-value computation. The performances of the algorithm are assessed via simulations. Its ability to discover new associations is demonstrated on a metagenomic dataset. The corresponding R package is available from https://github.com/abichat/zazou.

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Cites work

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Cited in

(2)

• A Bottom-Up Approach to Testing Hypotheses That Have a Branching Tree Dependence Structure, With Error Rate Control
• Asymptotic theory with hierarchical autocorrelation: Ornstein-Uhlenbeck tree models

Describes a project that uses

Uses Software

• zazou
• StructFDR
• R

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