Hierarchical correction of p-values via an ultrametric tree running Ornstein-Uhlenbeck process

DOI10.1007/S00180-021-01148-6zbMATH Open1505.62067arXiv2009.13335OpenAlexW3199344981MaRDI QIDQ2155000FDOQ2155000

Authors: Antoine Bichat, Christophe Ambroise, Mahendra Mariadassou 

Publication date: 15 July 2022

Published in: Computational Statistics (Search for Journal in Brave)

Abstract: Statistical testing is classically used as an exploratory tool to search for association between a phenotype and many possible explanatory variables. This approach often leads to multiple testing under dependence. We assume a hierarchical structure between tests via an Ornstein-Uhlenbeck process on a tree. The process correlation structure is used for smoothing the p-values. We design a penalized estimation of the mean of the Ornstein-Uhlenbeck process for p-value computation. The performances of the algorithm are assessed via simulations. Its ability to discover new associations is demonstrated on a metagenomic dataset. The corresponding R package is available from https://github.com/abichat/zazou.

Full work available at URL: https://arxiv.org/abs/2009.13335

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zbMATH Keywords

Lassomultiple testingOrnstein-Uhlenbeck processdebiasingFDR controlmetagenomic

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Applications of statistics to biology and medical sciences; meta analysis (62P10) Ridge regression; shrinkage estimators (Lasso) (62J07) Paired and multiple comparisons; multiple testing (62J15)

Cites Work

• Hierarchical inference for genome-wide association studies: a view on methodology with software
• Finite mixture models
• Title not available (Why is that?)
• Confidence Intervals and Hypothesis Testing for High-Dimensional Regression
• Hierarchical testing of variable importance
• Title not available (Why is that?)
• Confidence Intervals for Low Dimensional Parameters in High Dimensional Linear Models
• On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other
• The control of the false discovery rate in multiple testing under dependency.
• Scaled sparse linear regression
• False Discovery Rates for Spatial Signals
• Tuning Parameter Selection in High Dimensional Penalized Likelihood
• False discovery rate control via debiased Lasso
• Significance analysis of microarrays applied to the ionizing radiation response
• On the Time to Extinction in Recurrent Epidemics
• Title not available (Why is that?)
• Analyzing Microarray Gene Expression Data
• Analysis of Radio Telemetry Data in Studies of Home Range
• Hierarchical False Discovery Rate–Controlling Methodology
• Post hoc confidence bounds on false positives using reference families
• Spatial clustering of array CGH features in combination with hierarchical multiple testing
• Detection of Adaptive Shifts on Phylogenies by using Shifted Stochastic Processes on a Tree

Cited In (2)

• A Bottom-Up Approach to Testing Hypotheses That Have a Branching Tree Dependence Structure, With Error Rate Control
• Asymptotic theory with hierarchical autocorrelation: Ornstein-Uhlenbeck tree models

Uses Software

• R
• StructFDR
• zazou

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