A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level

DOI10.1007/S10827-022-00811-1zbMATH Open1494.92044OpenAlexW4225248014MaRDI QIDQ2163545FDOQ2163545

Authors: Damien Depannemaecker, Davide Lillo, Len Spek, A. V. Ivanov, Christophe P. Bernard, Viktor K. Jirsa 

Publication date: 10 August 2022

Published in: Journal of Computational Neuroscience (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s10827-022-00811-1

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zbMATH Keywords

bifurcationsslow-fast systemdepolarization blockseizuresbiophysical neuron modelstatus epilepticus

Mathematics Subject Classification ID

Neural biology (92C20) Pathology, pathophysiology (92C32)

Cites Work

• Fast-slow bursters in the unfolding of a high codimension singularity and the ultra-slow transitions of classes
• The role of extracellular potassium dynamics in the different stages of ictal bursting and spreading depression: A computational study
• Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms

Cited In (3)

• Mitochondrial dysfunction and role in spreading depolarization and seizure
• Interaction between synaptic inhibition and glial-potassium dynamics leads to diverse seizure transition modes in biophysical models of human focal seizures
• Transition and propagation of epilepsy in an improved epileptor model coupled with astrocyte

Uses Software

• SymPy
• Python

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