Bayesian local false discovery rate for sparse count data with application to the discovery of hotspots in protein domains

DOI10.1214/21-AOAS1551MaRDI QIDQ2170401zbMATH OpenFDO

Authors Iris Ivy M. Gauran, Junyong Park, Ilia Rattsev, Thomas A. Peterson, Maricel G. Kann, Dohwan Park

Publication date 5 September 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1214/21-AOAS1551

zbMATH Keywords

Bayesian local false discovery rateprotein domainssparse count datazero-inflated generalized Poisson

Mathematics Subject Classification ID

Bayesian inference (62F15) Paired and multiple comparisons; multiple testing (62J15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

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Cites work

• A Bayesian analysis of zero-inflated generalized Poisson model
• A Bayesian nonparametric multiple testing procedure for comparing several treatments against a control
• An exploration of aspects of Bayesian multiple testing
• Bayesian Models for Gene Expression With DNA Microarray Data
• Bayesian nonparametric multiple testing
• Detecting differential gene expression with a semiparametric hierarchical mixture method
• Empirical Bayes Analysis of a Microarray Experiment
• Empirical null estimation using zero-inflated discrete mixture distributions and its application to protein domain data
• Generalized Poisson distribution: the property of mixture of Poisson and comparison with negative binomial distribution
• Optimal Sample Size for Multiple Testing
• Overall objective priors

Cited in

(3)

• Hierarchical Bayesian analysis of somatic mutation data in cancer
• TRAB: testing whether mutation frequencies are above an unknown background
• False discovery rates in somatic mutation studies of cancer

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