Application of optimal control to influenza pneumonia coinfection with antiviral resistance

DOI10.1155/2020/5984095MaRDI QIDQ2176047zbMATH OpenOpenAlexWikidataFDO

Authors Caroline W. Kanyiri, Livingstone S. Luboobi, Mark Kimathi

Publication date 30 April 2020

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2020/5984095

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Applications of optimal control and differential games (49N90) Medical epidemiology (92C60) Epidemiology (92D30)

Review text

Summary: Influenza and pneumonia independently lead to high morbidity and mortality annually among the human population globally; however, a glaring fact is that influenza pneumonia coinfection is more vicious and it is a threat to public health. Emergence of antiviral resistance is a major impediment in the control of the coinfection. In this paper, a deterministic mathematical model illustrating the transmission dynamics of influenza pneumonia coinfection is formulated having incorporated antiviral resistance. Optimal control theory is then applied to investigate optimal strategies for controlling the coinfection using prevalence reduction and treatment as the system control variables. Pontryagin's maximum principle is used to characterize the optimal control. The derived optimality system is solved numerically using the Runge-Kutta-based forward-backward sweep method. Simulation results reveal that implementation of prevention measures is sufficient to eradicate influenza pneumonia coinfection from a given population. The prevention measures could be social distancing, vaccination, curbing mutation and reassortment, and curbing interspecies movement of the influenza virus.

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Cited in

(6)

• Optimal control in two strain pneumonia transmission dynamics
• Optimal control analysis of pneumonia and meningitis coinfection
• Optimal treatment profile during an influenza epidemic
• Impulsive optimal control for drug treatment of influenza A virus in the host with impulsive-axis equivalent model
• Optimal control strategies on HIV/AIDS and pneumonia co-infection with mathematical modelling approach
• A model for the transmission dynamics of pneumococcal pneumonia and influenza co-infection

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