An \textit{in silico} exploration of the neutral network in protein sequence space

DOI10.1006/JTBI.2003.3209MaRDI QIDQ2177153zbMATH OpenOpenAlexWikidataFDO

Authors Takuyo Aita, Motonori Ota, Yuzuru Husimi

Publication date 6 May 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1006/jtbi.2003.3209

Mathematics Subject Classification ID

Protein sequences, DNA sequences (92D20) Neural networks for/in biological studies, artificial life and related topics (92B20)

Recommendations

• Walking through protein sequence space
• Neutral networks of sequence to shape maps
• Replication and mutation on neutral networks
• Local connectivity of neutral networks
• scientific article; zbMATH DE number 874694

Cites work

• Chance and necessity in evolution: lessons from RNA
• Generic properties of combinatory maps: Neutral networks of RNA secondary structures
• Statistical formulae of the energy distribution among a globular protein structure ensemble

Cited in

(4)

• Walking through protein sequence space
• The role of weak selection and high mutation rates in nearly neutral evolution
• Cooperative ``folding transition in the sequence space facilitates function-driven evolution of protein families
• Selection originating from protein stability/foldability: relationships between protein folding free energy, sequence ensemble, and fitness

Describes a project that uses

Uses Software

• BLAST
• PSI-BLAST

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