Chance and necessity in evolution: lessons from RNA
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Publication:992177
DOI10.1016/S0167-2789(99)00076-7zbMATH Open1194.92060arXivphysics/9811037WikidataQ127571486 ScholiaQ127571486MaRDI QIDQ992177FDOQ992177
Peter Schuster, Walter Fontana
Publication date: 11 September 2010
Published in: Physica D (Search for Journal in Brave)
Abstract: The relationship between sequences and secondary structures or shapes in RNA exhibits robust statistical properties summarized by three notions: (1) the notion of a typical shape (that among all sequences of fixed length certain shapes are realized much more frequently than others), (2) the notion of shape space covering (that all typical shapes are realized in a small neighborhood of any random sequence), and (3) the notion of a neutral network (that sequences folding into the same typical shape form networks that percolate through sequence space). Neutral networks loosen the requirements on the mutation rate for selection to remain effective. The original (genotypic) error threshold has to be reformulated in terms of a phenotypic error threshold. With regard to adaptation, neutrality has two seemingly contradictory effects: It acts as a buffer against mutations ensuring that a phenotype is preserved. Yet it is deeply enabling, because it permits evolutionary change to occur by allowing the sequence context to vary silently until a single point mutation can become phenotypically consequential. Neutrality also influences predictability of adaptive trajectories in seemingly contradictory ways. On the one hand it increases the uncertainty of their genotypic trace. At the same time neutrality structures the access from one shape to another, thereby inducing a topology among RNA shapes which permits a distinction between continuous and discontinuous shape transformations. To the extent that adaptive trajectories must undergo such transformations, their phenotypic trace becomes more predictable.
Full work available at URL: https://arxiv.org/abs/physics/9811037
Recommendations
Biochemistry, molecular biology (92C40) Problems related to evolution (92D15) Neural networks for/in biological studies, artificial life and related topics (92B20)
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Cited In (7)
- A numerical investigation of adaptation in populations of random Boolean networks
- Evolutionary dynamics of a polymorphic self-replicator population with a finite population size and hyper mutation rate
- An \textit{in silico} exploration of the neutral network in protein sequence space
- Toward an evolutionary containment of evolving pathogen-receptors by using an ensemble of multiple mutant ligands: from the viewpoint of fitness landscape in sequence space
- Mathematical modelling of mutant accumulation kinetics in a cloned viral population
- Phenogenetic drift and the evolution of genotype-phenotype relationships. (Minireview)
- Statics and dynamics of multiple cubic autocatalytic reactions
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