Brownian dynamics simulation of nucleosome formation and disruption under stretching

DOI10.1016/J.JTBI.2004.03.028zbMATH Open1447.92142arXivq-bio/0312036OpenAlexW2139750159WikidataQ52559600 ScholiaQ52559600MaRDI QIDQ2186502FDOQ2186502

Authors: Yanyan Li 

Publication date: 9 June 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Using a Brownian dynamics simulation, we numerically studied the interaction of DNA with histone and proposed an octamer-rotation model to describe the process of nucleosome formation. Nucleosome disruption under stretching was also simulated. The theoretical curves of extension versus time as well as of force versus extension are consistent with previous experimental results.

Full work available at URL: https://arxiv.org/abs/q-bio/0312036

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zbMATH Keywords

DNAinteractionhistonenucleosome disruptionnucleosome formation

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Biochemistry, molecular biology (92C40)

Cited In (3)

• A Markov model for the dynamics of the nucleosome
• The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality
• Chromatin remodelers as active Brownian dimers

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