Dynamics of T cell activation threshold tuning

DOI10.1016/J.JTBI.2004.02.002MaRDI QIDQ2187651zbMATH OpenOpenAlexWikidataFDO

Authors D. A. Rand, Hugo A. van den Berg

Publication date 3 June 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2004.02.002

zbMATH Keywords

negative selectionT cell activationT cell toleranceTCR signallingtunable T cell activation threshold

Mathematics Subject Classification ID

Physiology (general) (92C30)

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Cites work

• Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
• scientific article; zbMATH DE number 3497683 (Why is no real title available?)
• Quantifying the strength of ligand antagonism in TCR triggering
• Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

Cited in

(22)

• Stochastic niche structure and diversity maintenance in the T cell repertoire
• Dependence of CD8 T cell response upon antigen load during primary infection.
• Dynamics of T cell receptor distributions following acute thymic atrophy and resumption
• Modeling the effect of activation of CD\(4^+\) T cells on HIV dynamics
• Time-delayed model of autoimmune dynamics
• Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
• Coreceptor CD8-driven modulation of T cell antigen receptor specificity
• Stochastic dynamics in a time-delayed model for autoimmunity
• T cell state transition produces an emergent change detector
• Immunological self-tolerance: Lessons from mathematical modeling
• The impact of multiple T cell\,-\,APC encounters and the role of anergy
• The role of tunable activation thresholds in the dynamics of autoimmunity
• Optimal T cell cross-reactivity and the role of regulatory T cells
• Structural and functional robustness of the adaptive-sorting signaling network
• scientific article; zbMATH DE number 596334 (Why is no real title available?)
• COMPARISON OF A DUAL STRATEGY FOR T-CELL ACTIVATION UNDER INHIBITION OF THE CD4 RECEPTOR
• Bifurcations and multistability in a model of cytokine-mediated autoimmunity
• Dynamic regulation of T cell activation by coupled feedforward loops
• The effect of chemotaxis on T-cell regulatory dynamics
• The influence of T cell development on pathogen specificity and autoreactivity
• Quantifying T lymphocyte turnover
• Emergent group dynamics governed by regulatory cells produce a robust primary T cell response

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