Optimal experimental designs for treatment contrasts in heteroscedastic models with covariates
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Publication:2189115
Abstract: In clinical trials, the response of a given subject often depends on the selected treatment as well as on some covariates. We study optimal approximate designs of experiments in the models with treatment and covariate effects. We allow for the variances of the responses to depend on the chosen treatments, which introduces heteroscedasticity into the models. For estimating systems of treatment contrasts and linear functions of the covariates, we extend known results on D-optimality of product designs by providing product designs that are optimal with respect to general eigenvalue-based criteria. In particular, A- and E-optimal product designs are obtained. We then formulate a method based on linear programming for constructing optimal designs with smaller supports from the optimal product designs. The sparser designs can be more easily converted to practically applicable exact designs. The provided results and the proposed sparsification method are demonstrated on some examples.
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Cited in
(10)- Optimum designs for two treatments with unequal variances in the presence of covariates
- Optimal designs for semi-parametric dose-response models under random contamination
- Optimal and efficient treatment control design in the heteroscedastic one-way layout with covariates
- Bayesian optimal experimental design for treatment-control comparisons in the presence of two-way heterogeneity
- Optimum Designs for Non-Linear Mixed Effects Models in the Presence of Covariates
- Optimal designs for multiple treatments with unequal variances
- Optimal approximate designs for estimating treatment contrasts resistant to nuisance effects
- On the design of experiments in the presence of fixed covariates
- Optimal designs for dose-response models with linear effects of covariates
- Optimal and efficient designs for comparing a set of test treatments with a set of controls in a heteroscedastic one-way layout with covariates
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