Hodgkin-Huxley type ion channel characterization: an improved method of voltage clamp experiment parameter estimation

DOI10.1016/J.JTBI.2006.02.006MaRDI QIDQ2201833zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 17 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.02.006

zbMATH Keywords

parameter estimationfittingcell modelvoltage clampHodgkin-Huxley

Mathematics Subject Classification ID

Cell biology (92C37)

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Cites work

• A Hodgkin-Huxley model exhibiting bursting oscillations
• A Simplex Method for Function Minimization
• Convergence Properties of the Nelder--Mead Simplex Method in Low Dimensions

Cited in

(10)

• Discerning ionic currents and their kinetics from input impedance data
• A new algorithm for voltage clamp by iteration: A learning control of a nonlinear neuronal system
• Exploring voltage-dependent ion channels in silico by hysteretic conductance
• Corrections for space-clamp errors in measured parameters of voltage-dependent conductances in a cylindrical neurite
• Simulations of space-clamp errors in estimating parameters of voltage-gated conductances localized at different electrotonic distances
• On the interpretation of voltage-clamp data using the Hodgkin-Huxley model
• The use of automated parameter searches to improve ion channel kinetics for neural modeling
• Estimation of biophysical parameters in a neuron model under random fluctuations
• Estimability analysis and optimal design in dynamic multi-scale models of cardiac electrophysiology
• Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

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Uses Software

• fminsearch

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