The adaptive filter of the yeast galactose pathway

DOI10.1016/J.JTBI.2006.03.005zbMATH Open1447.92153arXivq-bio/0604012OpenAlexW1997241456WikidataQ83212435 ScholiaQ83212435MaRDI QIDQ2201877FDOQ2201877

François Képès, Vincent Schächter, Serge Smidtas

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: In the yeast Saccharomyces cerevisiae, the interplay between galactose, Gal3p, Gal80p and Gal4p determines the transcriptional status of the genes required for galactose utilization. After an increase in galactose concentration, galactose molecules bind onto Gal3p. This event leads via Gal80p to the activation of Gal4p, which then induces GAL3 and GAL80 gene transcription. Here we propose a qualitative dynamic model, whereby these molecular interaction events represent the first two stages of a functional feedback loop that closes with the capture of activated Gal4p by newly synthesized Gal3p and Gal80p, decreasing transcriptional activation and creating again the protein complex that can bind incoming galactose molecules. Based on the differential time scales of faster protein interactions versus slower biosynthetic steps, this feedback loop functions as a derivative filter where galactose is the input step signal, and released Gal4p is the output derivative signal. One advantage of such a derivative filter is that GAL genes are expressed in proportion to the cellular requirement. Furthermore, this filter adaptively protects the cellular receptors from saturation by galactose, allowing cells to remain sensitive to variations in galactose concentrations rather than to absolute concentrations. Finally, this feedback loop, by allowing phosphorylation of some active Gal4p, may be essential to initiate the subsequent long-term response.

Full work available at URL: https://arxiv.org/abs/q-bio/0604012

zbMATH Keywords

feedback loopyeastinteraction networksqualitative modelingadaptive filtergalactose switch

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Cites Work

• A two variable delay model for the circadian rhythm of \textit{Neurospora crassa}

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• Understanding start-up problems in yeast glycolysis

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