Monte Carlo sampling and principal component analysis of flux distributions yield topological and modular information on metabolic networks

DOI10.1016/J.JTBI.2006.03.007zbMATH Open1447.92174OpenAlexW1995365737WikidataQ51157665 ScholiaQ51157665MaRDI QIDQ2201883FDOQ2201883

Authors: Berna Sarıyar, Sinem Perk, Uğur Akman, Amable Hortaçsu 

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2006.03.007

Recommendations

• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space
• Structural analysis of metabolic networks based on flux centrality
• Flux modules in metabolic networks
• Systemic metabolic reactions are obtained by singular value decomposition of genome-scale stoichiometric matrices
• Modular decomposition of metabolic systems via null-space analysis

zbMATH Keywords

linear programmingMonte Carlo samplingprincipal component analysisflux balance analysismodular information

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites Work

• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space

Cited In (3)

• Modular decomposition of metabolic systems via null-space analysis
• Flux modules in metabolic networks
• Structural analysis of metabolic networks based on flux centrality

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