Monte Carlo sampling and principal component analysis of flux distributions yield topological and modular information on metabolic networks

DOI10.1016/J.JTBI.2006.03.007MaRDI QIDQ2201883zbMATH OpenOpenAlexWikidataFDO

Authors Berna Sarıyar, Sinem Perk, Uğur Akman, Amable Hortaçsu

Publication date 17 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.03.007

zbMATH Keywords

linear programmingMonte Carlo samplingprincipal component analysisflux balance analysismodular information

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Recommendations

• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space
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Cites work

• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space

Cited in

(4)

• Modular decomposition of metabolic systems via null-space analysis
• Flux modules in metabolic networks
• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space
• Structural analysis of metabolic networks based on flux centrality

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