Incorporating energy metabolism into a growth model of multicellular tumor spheroids

DOI10.1016/J.JTBI.2006.03.011MaRDI QIDQ2201895zbMATHOpenAlexWikidataFDO

Authors Raja Venkatasubramanian, Michael A. Henson, Neil S. Forbes

Publication date 17 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.03.011

zbMATH Keywords

diffusionquiescencehypoxiaenergy metabolismtumor growth modelingmulticellular tumor spheroid

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37) Pathology, pathophysiology (92C32)

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Cites work

• scientific article; zbMATH DE number 3871841 (Why is no real title available?)
• scientific article; zbMATH DE number 1320551 (Why is no real title available?)
• scientific article; zbMATH DE number 1005391 (Why is no real title available?)
• A history of the study of solid tumour growth: the contribution of mathematical modelling
• A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
• A new mathematical model for avascular tumour growth
• Diffusion regulated growth characteristics of a spherical prevascular carcinoma
• Growth of nonnecrotic tumors in the presence and absence of inhibitors
• Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures
• Mathematical models of tumor growth. IV: Effects of a necrotic core
• On the concentration profile of a growth inhibitory factor in multicell spheroids
• Regression and regrowth of tumour cords following single-dose anticancer treatment
• The migration of cells in multicell tumor spheroids
• The role of acidity in solid tumour growth and invasion
• Using Krylov Methods in the Solution of Large-Scale Differential-Algebraic Systems

Cited in

(21)

• Adjoint method for a tumor growth PDE-constrained optimization problem
• Necrotic core in EMT6/Ro tumour spheroids: is it caused by an ATP deficit?
• Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
• A quantitative theoretical model for the development of malignancy in ductal carcinoma \textit{in situ}
• The steady state of multicellular tumour spheroids: a modelling challenge
• A free boundary problem of the cancer invasion
• Slow and fast invasion waves in a model of acid-mediated tumour growth
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Solvability of the acid-mediated tumor growth model with nonlinear acid production term
• A microscale mathematical model for metabolic symbiosis: investigating the effects of metabolic inhibition on ATP turnover in tumors
• Renormalized and entropy solutions of tumor growth model with nonlinear acid production
• A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth
• Comparison of drug inhibitory effects \((\mathrm{IC}_{50})\) in monolayer and spheroid cultures
• A quantitative cellular automaton model of in vitro multicellular spheroid tumour growth
• Tumour glycolysis: the many faces of HIF
• Metabolic changes during carcinogenesis: potential impact on invasiveness
• A general reaction-diffusion model of acidity in cancer invasion
• Mathematical modelling of the Warburg effect in tumour cords
• Modelling acidosis and the cell cycle in multicellular tumour spheroids
• A numerical model of EMT6/Ro spheroid dynamics under irradiation: calibration and estimation of the underlying irradiation-induced cell survival probability
• A model combining acid-mediated tumour invasion and nutrient dynamics

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