A microscale mathematical model for metabolic symbiosis: investigating the effects of metabolic inhibition on ATP turnover in tumors

DOI10.1016/J.JTBI.2014.11.016zbMath1412.92102OpenAlexW2048652043WikidataQ51006461 ScholiaQ51006461MaRDI QIDQ2415751

Mohammad Kohandel, Colin Phipps, Hamid Molavian

Publication date: 23 May 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2014.11.016

zbMATH Keywords

:tumor hypoxiacancer cell metabolismglycolytic inhibitionlactate dehydrogenase inhibitorwarburg effect

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Related Items (1)

A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment

Uses Software

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Cites Work

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• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• Necrotic core in EMT6/Ro tumour spheroids: is it caused by an ATP deficit?
• Incorporating energy metabolism into a growth model of multicellular tumor spheroids
• Cell resensitization after delivery of a cycle-specific anticancer drug and effect of dose splitting: learning from tumour cords
• ATP Production and Necrosis Formation in a Tumour Spheroid Model

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