A microscale mathematical model for metabolic symbiosis: investigating the effects of metabolic inhibition on ATP turnover in tumors

DOI10.1016/J.JTBI.2014.11.016MaRDI QIDQ2415751zbMATH OpenOpenAlexWikidataFDO

Authors Colin Phipps, Hamid Molavian, Mohammad Kohandel

Publication date 23 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.11.016

zbMATH Keywords

:tumor hypoxiacancer cell metabolismglycolytic inhibitionlactate dehydrogenase inhibitorwarburg effect

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• scientific article; zbMATH DE number 1531850 (Why is no real title available?)
• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• ATP production and necrosis formation in a tumour spheroid model
• Cell resensitization after delivery of a cycle-specific anticancer drug and effect of dose splitting: learning from tumour cords
• Incorporating energy metabolism into a growth model of multicellular tumor spheroids
• Necrotic core in EMT6/Ro tumour spheroids: is it caused by an ATP deficit?

Cited in

(8)

• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy
• A mathematical model for imaging and killing cancer cells by using concepts of the Warburg effect in designing a graphene system
• DDQN-based optimal targeted therapy with reversible inhibitors to combat the Warburg effect
• p53 orchestrates cancer metabolism: unveiling strategies to reverse the Warburg effect
• A theoretical explanation of the laws of Warburg and Sigmond
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Incorporating energy metabolism into a growth model of multicellular tumor spheroids

Describes a project that uses

Uses Software

• Matlab

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