DDQN-based optimal targeted therapy with reversible inhibitors to combat the Warburg effect

DOI10.1016/J.MBS.2023.109044MaRDI QIDQ6178607zbMATH OpenFDO

Authors Jose M. Sanz Nogales, Juan Parras, S. Zazo

Publication date 4 September 2023

Published in Mathematical Biosciences (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/J.MBS.2023.109044

zbMATH Keywords

AR-C155858double deep Q-networksgenisteinoptimal inhibition targeted therapyWarburg effect

Mathematics Subject Classification ID

Artificial neural networks and deep learning (68T07) Medical applications (general) (92C50)

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Cites work

• An evolutionary dynamics model for metastatic tumour growth based on public goods games
• Dynamic control of stochastic evolution: a deep reinforcement learning approach to adaptively targeting emergent drug resistance
• Dynamic programming and optimal control. Vol. 2
• Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells
• scientific article; zbMATH DE number 5869530 (Why is no real title available?)
• Optimal control strategy for cancer remission using combinatorial therapy: a mathematical model-based approach
• Optimal treatment strategies for delayed cancer-immune system with multiple therapeutic approach
• Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment
• Reinforcement learning. An introduction
• Stochastic dynamics of Michaelis-Menten kinetics based tumor-immune interactions
• The replicator equation and other game dynamics

Cited in

(2)

• Nonlinear multi-objective flux balance analysis of the Warburg Effect
• p53 orchestrates cancer metabolism: unveiling strategies to reverse the Warburg effect

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