Local immunodeficiency: role of neutral viruses

DOI10.1007/S11538-020-00813-ZMaRDI QIDQ2211769zbMATH OpenOpenAlexWikidataFDO

Authors Longmei Shu, Leonid A. Bunimovich

Publication date 13 November 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2003.04837

zbMATH Keywords

altruistic and persistent virusescross-immunoreactivity networklocal immunodeficiencyneutral

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32) Systems biology, networks (92C42)

Abstract: This paper analyzes the role of neutral viruses in the phenomenon of local immunodeficiency. We show that, even in the absence of altruistic viruses, neutral viruses can support the existence of persistent viruses, and thus local immunodeficiency. However, in all such cases neutral viruses can maintain only bounded (relatively small) concentration of persistent viruses. Moreover, in all such cases the state of local immunodeficiency could only be marginally stable, while it is known that altruistic viruses can maintain stable local immunodeficiency. We also present an absolutely minimal cross-immunoreactivity network where a stable and robust state of local immunodeficiency can be maintained. It is now a challenge to synthetic biology to build such small networks with stable local immunodeficiency. Another important challenge for biology is to understand which types of viruses can play a role of persistent, altrustic and neutral ones, and whether a role which a given virus plays depends on the structure (topology) of a given cross-immunoreactivity network.

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Cites work

• scientific article; zbMATH DE number 2038872 (Why is no real title available?)
• Local immunodeficiency: minimal networks and stability
• Mathematical biology of HIV infections: Antigenic variation and diversity threshold
• Ordinary differential equations with applications

Cited in

(3)

• Local immunodeficiency: minimal networks and stability
• Antigenic cooperation in viral populations: transformation of functions of intra-host viral variants
• Antigenic cooperation in viral populations: maximal load on viruses and self-sufficiency of persistent viruses

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