Approximate Bayesian inference for mixture cure models

DOI10.1007/S11749-019-00679-XzbMATH Open1458.62225arXiv1806.09362OpenAlexW2977014755WikidataQ127210240 ScholiaQ127210240MaRDI QIDQ2220802FDOQ2220802

Authors: E. Lázaro, Carmen Armero, Virgilio Gómez-Rubio 

Publication date: 25 January 2021

Published in: Test (Search for Journal in Brave)

Abstract: Cure models in survival analysis deal with populations in which a part of the individuals cannot experience the event of interest. Mixture cure models consider the target population as a mixture of susceptible and non-susceptible individuals. The statistical analysis of these models focuses on examining the probability of cure (incidence model) and inferring on the time-to-event in the susceptible subpopulation (latency model). Bayesian inference on mixture cure models has typically relied upon Markov chain Monte Carlo (MCMC) methods. The integrated nested Laplace approximation (INLA) is a recent and attractive approach for doing Bayesian inference. INLA in its natural definition cannot fit mixture models but recent research has new proposals that combine INLA and MCMC methods to extend its applicability to them (Bivand et al., 2014, G'omez-Rubio et al., 2017, G'omez-Rubio and Rue, 2018}. This paper focuses on the implementation of INLA in mixture cure models. A general mixture cure survival model with covariate information for the latency and the incidence model within a general scenario with censored and non-censored information is discussed. The fact that non-censored individuals undoubtedly belong to the uncured population is a valuable information that was incorporated in the inferential process.

Full work available at URL: https://arxiv.org/abs/1806.09362

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• scientific article; zbMATH DE number 5499390

zbMATH Keywords

survival analysisGibbs samplingaccelerated failure time mixture cure modelscomplete and marginal likelihood functionproportional hazards mixture cure models

Mathematics Subject Classification ID

Bayesian inference (62F15) Estimation in survival analysis and censored data (62N02) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Gaussian Markov Random Fields
• Inference from iterative simulation using multiple sequences
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• Dealing With Label Switching in Mixture Models
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• Markov chain Monte Carlo with the integrated nested Laplace approximation
• Approximate Bayesian inference for survival models
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• Limited Failure Population Life Tests: Application to Integrated Circuit Reliability
• Estimating and modeling the cure fraction in population-based cancer survival analysis

Cited In (8)

• Bayesian and likelihood inference for cure rates based on defective inverse Gaussian regression models
• An Approximate Bayesian Marginal Likelihood Approach for Estimating Finite Mixtures
• Approximate Bayesian inference for survival models
• Laplacian-P-splines for Bayesian inference in the mixture cure model
• On the likelihood of mixture cure models
• Fitting double hierarchical models with the integrated nested Laplace approximation
• Fast Bayesian inference using Laplace approximations in a flexible promotion time cure model based on P-splines
• A Bayesian approach to mixture cure models with spatial frailties for population-based cancer relative survival data

Uses Software

• R
• GMRFLib
• R-INLA
• JAGS
• Smcure

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