Approximate Bayesian inference for mixture cure models
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Abstract: Cure models in survival analysis deal with populations in which a part of the individuals cannot experience the event of interest. Mixture cure models consider the target population as a mixture of susceptible and non-susceptible individuals. The statistical analysis of these models focuses on examining the probability of cure (incidence model) and inferring on the time-to-event in the susceptible subpopulation (latency model). Bayesian inference on mixture cure models has typically relied upon Markov chain Monte Carlo (MCMC) methods. The integrated nested Laplace approximation (INLA) is a recent and attractive approach for doing Bayesian inference. INLA in its natural definition cannot fit mixture models but recent research has new proposals that combine INLA and MCMC methods to extend its applicability to them (Bivand et al., 2014, G'omez-Rubio et al., 2017, G'omez-Rubio and Rue, 2018}. This paper focuses on the implementation of INLA in mixture cure models. A general mixture cure survival model with covariate information for the latency and the incidence model within a general scenario with censored and non-censored information is discussed. The fact that non-censored individuals undoubtedly belong to the uncured population is a valuable information that was incorporated in the inferential process.
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- scientific article; zbMATH DE number 5499390
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- Estimating and modeling the cure fraction in population-based cancer survival analysis
- Gaussian Markov Random Fields
- Geoadditive Survival Models
- Inference from iterative simulation using multiple sequences
- Limited Failure Population Life Tests: Application to Integrated Circuit Reliability
- Markov chain Monte Carlo with the integrated nested Laplace approximation
Cited in
(8)- A Bayesian approach to mixture cure models with spatial frailties for population-based cancer relative survival data
- Approximate Bayesian inference for survival models
- Bayesian and likelihood inference for cure rates based on defective inverse Gaussian regression models
- Fast Bayesian inference using Laplace approximations in a flexible promotion time cure model based on P-splines
- Laplacian-P-splines for Bayesian inference in the mixture cure model
- On the likelihood of mixture cure models
- Fitting double hierarchical models with the integrated nested Laplace approximation
- An Approximate Bayesian Marginal Likelihood Approach for Estimating Finite Mixtures
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