Unbounded solutions of models for glycolysis

DOI10.1007/S00285-021-01560-YMaRDI QIDQ2223247zbMATH OpenOpenAlexWikidataFDO

Authors Pia Brechmann, Alan D. Rendall

Publication date 28 January 2021

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2003.07140

zbMATH Keywords

dynamical systemglycolysisoscillations

Mathematics Subject Classification ID

Growth and boundedness of solutions to ordinary differential equations (34C11) Dynamical systems in biology (37N25) Biochemistry, molecular biology (92C40)

Abstract: The Selkov oscillator, a simple description of glycolysis, is a system of two ordinary differential equations with mass action kinetics. In previous work the authors established several properties of the solutions of this system. In the present paper we extend this to prove that this system has solutions which diverge to infinity in an oscillatory manner at late times. This system was originally derived from another system with Michaelis-Menten kinetics. It is shown that the Michaelis-Menten system, like that with mass action, has solutions which diverge to infinity in a monotone manner. It is also shown to admit subcritical Hopf bifurcations and thus unstable periodic solutions. We discuss to what extent the unbounded solutions cast doubt on the biological relevance of the Selkov oscillator and compare it with other models in the literature.

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Cited in

(14)

• Local and global bifurcations at infinity in models of glycolytic oscillations
• A comparative analysis of kinetic models of erythrocyte glycolysis
• Uniqueness and global attractivity of glycolytic oscillations suggested by Selkov's model
• Dynamics of the Higgins-Selkov and Selkov systems
• Phase portraits of the Higgins-Selkov system
• Transient behavior towards the stable limit cycle in the Sel'kov model of glycolysis: a physiological disorder
• Modelling lockdown measures in epidemic outbreaks using selective socio-economic containment with uncertainty
• A stochastic metapopulation state-space approach to modeling and estimating COVID-19 spread
• Optimization strategies of human mobility during the COVID-19 pandemic: a review
• scientific article; zbMATH DE number 3845396 (Why is no real title available?)
• A positively invariant region for the extended simplified glycolysis model
• scientific article; zbMATH DE number 1471746 (Why is no real title available?)
• External forcing in a glycolytic model
• Qualitative study of the Selkov model

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