Control intervention strategies for within-host, between-host and their efficacy in the treatment, spread of COVID-19 : a multi scale modeling approach

DOI10.1515/CMB-2020-0111MaRDI QIDQ2236670zbMATH OpenOpenAlexWikidataFDO

Authors D. Bhanu Prakash, D. K. K. Vamsi, D. Bangaru Rajesh, Carani B. Sanjeevi

Publication date 26 October 2021

Published in Computational and Mathematical Biophysics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2009.11568

zbMATH Keywords

COVID-19within-hostbetween-hostcomparative effectivenessmulti scale modeling

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30) Qualitative investigation and simulation of ordinary differential equation models (34C60)

Abstract: The COVID-19 pandemic has resulted in more than 14.5 million infections and 6,04,917 deaths in 212 countries over the last few months. Different drug intervention acting at multiple stages of pathogenesis of COVID-19 can substantially reduce the infection induced,thereby decreasing the mortality. Also population level control strategies can reduce the spread of the COVID-19 substantially. Motivated by these observations, in this work we propose and study a multi scale model linking both within-host and between-host dynamics of COVID-19. Initially the natural history dealing with the disease dynamics is studied. Later, comparative effectiveness is performed to understand the efficacy of both the within-host and population level interventions. Findings of this study suggest that a combined strategy involving treatment with drugs such as Arbidol, remdesivir, Lopinavir/Ritonavir that inhibits viral replication and immunotherapies like monoclonal antibodies, along with environmental hygiene and generalized social distancing proved to be the best and optimal in reducing the basic reproduction number and environmental spread of the virus at the population level.

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Cites work

• Development and application of multiscale models of acute viral infections in intervention research
• Modelling of transmission dynamics of Nipah virus (Niv): a fractional order approach
• Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
• The within-host viral kinetics of SARS-CoV-2

Cited in

(6)

• Stability and bifurcation analysis of a nested multi-scale model for COVID-19 viral infection
• Discussion on: ``The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control method
• Coupling the within-host process and between-host transmission of COVID-19 suggests vaccination and school closures are critical
• Discussion on: ``The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control method
• Alternative SIAR models for infectious diseases and applications in the study of non-compliance
• Analysis of a Reaction-Diffusion SIR Epidemic Model with Noncompliant Behavior

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