Validation study methods for estimating odds ratio in 22 J tables when exposure is misclassified
Summary: Misclassification of exposure variables in epidemiologic studies may lead to biased estimation of parameters and loss of power in statistical inferences. In this paper, the inverse matrix method, as an efficient method of the correction of odds ratio for the misclassification of a binary exposure, was generalized to nondifferential misclassification and \(2\times2\times J\) tables. Simple estimates for predictive values when misclassification is nondifferential are presented. Using them, we estimated the corrected log odds ratio and its variance for \(2\times2\times J\) tables, using the inverse matrix method. A two-step weighted likelihood method was also developed. Moreover, we compared the matrix and inverse matrix methods to the maximum likelihood (MLE) method using a simulation study. In all situations, the inverse matrix method proved to be more efficient than the matrix method. Matrix and inverse matrix methods for nondifferential situations are more efficient than differential misclassification. Although MLE is optimal among all of the methods, it is computationally difficult and requires programming. On the other hand, the inverse matrix method with a simple closed-form presents acceptable efficiency.
- Matrix Methods for Estimating Odds Ratios with Misclassified Exposure Data: Extensions and Comparisons
- Can efficiency be gained by correcting for misclassification?
- A note on estimating crude odds ratios in case-control studies with differentially misclassified exposure
- Extended matrix and inverse matrix methods utilizing internal validation data when both disease and exposure status are misclassified
- Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure Is Misclassified
- Odds ratios estimation of rare event in binomial distribution
- Maximum-likelihood and closed-form estimators of epidemiologic measures under misclassifi\-ca\-tion
- Extended matrix and inverse matrix methods utilizing internal validation data when both disease and exposure status are misclassified
- A note on estimating crude odds ratios in case-control studies with differentially misclassified exposure
- Can efficiency be gained by correcting for misclassification?
- Matrix Methods for Estimating Odds Ratios with Misclassified Exposure Data: Extensions and Comparisons
- Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure Is Misclassified
- When exposure is subject to nondifferential misclassification, are validation data helpful in testing for an exposure-disease association?
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