An alternative sensitivity approach for longitudinal analysis with dropout

DOI10.1155/2019/1019303MaRDI QIDQ2272849zbMATH OpenOpenAlexFDO

Authors Amal Almohisen, Robin Henderson, Arwa M. Alshingiti

Publication date 17 September 2019

Published in Journal of Probability and Statistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2019/1019303

Mathematics Subject Classification ID

Missing data (62D10) Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Review text

Summary: In any longitudinal study, a dropout before the final timepoint can rarely be avoided. The chosen dropout model is commonly one of these types: Missing Completely at Random (MCAR), Missing at Random (MAR), Missing Not at Random (MNAR), and Shared Parameter (SP). In this paper we estimate the parameters of the longitudinal model for simulated data and real data using the Linear Mixed Effect (LME) method. We investigate the consequences of misspecifying the missingness mechanism by deriving the so-called least false values. These are the values the parameter estimates converge to, when the assumptions may be wrong. The knowledge of the least false values allows us to conduct a sensitivity analysis, which is illustrated. This method provides an alternative to a local misspecification sensitivity procedure, which has been developed for likelihood-based analysis. We compare the results obtained by the method proposed with the results found by using the local misspecification method. We apply the local misspecification and least false methods to estimate the bias and sensitivity of parameter estimates for a clinical trial example.

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Cited in

(2)

• A sensitivity analysis approach for informative dropout using shared parameter models
• Time Series Analysis for Longitudinal Survey Data Under Informative Sampling and Nonignorable Missingness

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