A discrete non-linear Markov model for a population of interacting cells

DOI10.1016/0304-4149(91)90058-KMaRDI QIDQ2277679zbMATH OpenFDO

Authors Anna Gerardi, Matteo Romiti

Publication date 1991

Published in Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0304-4149(91)90058-K

zbMATH Keywords

cell cycle analysisfixed point techniquespure jump non-linear Markov process

Mathematics Subject Classification ID

Limit theorems for vector-valued random variables (infinite-dimensional case) (60B12) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Interacting random processes; statistical mechanics type models; percolation theory (60K35) Genetics and epigenetics (92D10) Ecology (92D40)

Review text

The biological problem considered in this paper is cell cycle analysis. Evidently, the discrete part of the formulation stems from by viewing the DNA contents of cells in terms of a finite set of numbers. However, the time parameter in the formulation is continuous. In order to take into account crowding effects, growth of a cell population is modelled as a pure jump non-linear Markov process. Existence and uniqueness of solutions for the corresponding martingale problem are proved by means of fixed point techniques. There is a large literature on cell cycle analysis in various biological and biomathematics journals. But, unfortunately, none of this literature is cited. It is, therefore, difficult to judge where this paper fits into a more general picture. There are also good reasons to question the efficacy of existence theorems in applications. In this computer age, methods of constructing solutions seem much more pertinent for applications so that a user may begin to experiment and understand the model with respect to competing formulations.

Recommendations

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Cites work

• A CLASS OF MARKOV PROCESSES ASSOCIATED WITH NONLINEAR PARABOLIC EQUATIONS
• scientific article; zbMATH DE number 3928057 (Why is no real title available?)
• scientific article; zbMATH DE number 3951715 (Why is no real title available?)
• scientific article; zbMATH DE number 3664138 (Why is no real title available?)
• Law of Large Numbers for DNA Distribution in an Interacting Cell Population
• Limit laws for a coagulation model of interacting random particles
• Martingale Approach for Modeling DNA Synthesis
• Mathematical models of the cell cycle with a view to tumor studies

Cited in

(3)

• A non-Markovian model for cell population growth: speed of convergence and central limit theorem
• Analytic formulas for discrete stochastic models of cell populations with both differentiation and de-differentiation
• Law of Large Numbers for DNA Distribution in an Interacting Cell Population

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