Multi-kernel unmixing and super-resolution using the modified matrix pencil method
DNA sequencingmixture modelsmodified matrix pencil methodmulti-kernel unmixing super-resolution problemsignal recoverystreams of Dirac'ssuper-resolution
Matrix pencils (15A22) Toeplitz, Cauchy, and related matrices (15B05) Fourier and Fourier-Stieltjes transforms and other transforms of Fourier type (42A38) Positive definite functions in one variable harmonic analysis (42A82) Numerical computation of eigenvalues and eigenvectors of matrices (65F15) Protein sequences, DNA sequences (92D20) Signal theory (characterization, reconstruction, filtering, etc.) (94A12)
In this excellent paper, the authors consider a generalization of the standard super-resolution problem, the so-called \textit{multi-kernel unmixing super-resolution problem}. They consider signals \[ x(t) = \sum_{\ell = 1}^L x_{\ell}(t)\,, \quad t\in \mathbb R\,, \] where \[ x_{\ell}(t) = \sum_{j=1}^K u_{\ell,j}\, \delta(t - t_{\ell,j})\,, \quad \ell=1,\ldots ,L\,, \] are streams of Dirac's with locations \(t_{\ell,j}\in [0,\,1)\) and coefficients \(u_{\ell,j}\in \mathbb C\). Let \(g_{\ell}(t) = g(t/\mu_{\ell})\), \(\ell=1,\ldots, L\) be Gaussian kernels with \(g(t) = \exp(- t^2/2)\) and positive variance parameters \(\mu_1 < \ldots < \mu_L\). Let \(f(s) = (Fy)(s)\) be the Fourier transform of \[ y(t) = \sum_{\ell = 1}^L (g_{\ell} \ast x_{\ell})(t) \] such that \[ f(s) = \sum_{\ell = 1}^L (F g_{\ell})(s)\, (F x_{\ell})(s)\,. \] Then the aim of the multi-kernel unmixing super-resolution problem is to recover estimates of all locations \(t_{\ell,j}\) and coefficients \(u_{\ell,j}\) from few noisy samples of \(f(s)\). This problem has important practical applications such as in single molecule spectroscopy, spike sorting in neuron activity analysis, DNA sequencing, or spike hunting in galaxy spectra. The main idea of the algorithm is based on stepwise computation of the locations and coefficients for \(\ell = 1,\ldots,L\). In the first step \(\ell = 1\) for noiseless data, one uses the fact that \(f(s)/(Fg_1)(s)\) is approximately equal to the exponential sum \[ (F x_1)(s) = \sum_{j=1}^K u_{1,j}\, \exp(2\pi {\mathrm i}\,t_{1,j}\,s)\,, \quad s \ge s_1 \gg 1\,. \] Using a modified matrix pencil method, one can determine \(t_{1,j}\) and \(u_{1,j}\) for \(j=1,\ldots, K\). In the second step \(\ell = 2\), one considers \(f(s) - (F g_1)(s)\, (F x_1)(s)\) for \(s\ge s_2> s_1\) and computes \(t_{2,j}\) and \(u_{2,j}\) for \(j=1,\ldots, K\) by a similar technique and so on. A highlight of these results is the fact that in all estimates the authors present explicit bounds. In many numerical experiments, signals with \(L=4\) and \(K\in \{2,\,3,\,4,\,5\}\) are considered.
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