Data-driven analysis of a mechanistic model of CAR T cell signaling predicts effects of cell-to-cell heterogeneity

DOI10.1016/J.JTBI.2019.110125zbMATH Open1430.92029OpenAlexW2996109087WikidataQ92185064 ScholiaQ92185064MaRDI QIDQ2295757FDOQ2295757

Authors: Colin G. Cess, Stacey D. Finley 

Publication date: 17 February 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2019.110125

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zbMATH Keywords

computational modelingpartial least-squaresintracellular signaling

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37)

Cites Work

• Simulating brain tumor heterogeneity with a multiscale agent-based model: Linking molecular signatures, phenotypes and expansion rate
• A computational model for investigating tumor apoptosis induced by mesenchymal stem cell-derived secretome

Cited In (2)

• Elucidation of T cell signalling models
• A stochastic framework for evaluating CAR T cell therapy efficacy and variability

Uses Software

• BioNetGen

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