Data-driven analysis of a mechanistic model of CAR T cell signaling predicts effects of cell-to-cell heterogeneity

DOI10.1016/J.JTBI.2019.110125MaRDI QIDQ2295757zbMATH OpenOpenAlexWikidataFDO

Authors Colin G. Cess, Stacey D. Finley

Publication date 17 February 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2019.110125

zbMATH Keywords

computational modelingpartial least-squaresintracellular signaling

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37)

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Cites work

• A computational model for investigating tumor apoptosis induced by mesenchymal stem cell-derived secretome
• Simulating brain tumor heterogeneity with a multiscale agent-based model: Linking molecular signatures, phenotypes and expansion rate

Cited in

(2)

• Elucidation of T cell signalling models
• A stochastic framework for evaluating CAR T cell therapy efficacy and variability

Describes a project that uses

Uses Software

• BioNetGen

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