Statistical characteristics of the first passage time analysis for the gene regulatory circuit in \textit{Bacillus subtilis} by cell mapping method

DOI10.1155/2020/3062859MaRDI QIDQ2296261zbMATH OpenOpenAlexWikidataFDO

Authors Liang Wang, Minjuan Yuan, Shichao Ma, Xiaole Yue, Ying Zhang

Publication date 18 February 2020

Published in Complexity (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2020/3062859

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Review text

Summary: In this paper, we will explore the stochastic exit problem for the gene regulatory circuit in \textit{B. subtilis} affected by colored noise. The stochastic exit problem studies the state transition in \textit{B. subtilis} (from competent state to vegetative state in this case) through three different quantities: the probability density function of the first passage time, the mean of first passage time, and the reliability function. To satisfy the Markov nature, we convert the colored noise system into the equivalent white noise system. Then, the stochastic generalized cell mapping method can be used to explore the stochastic exit problem. The results indicate that the intensity of noise and system parameters have the effect on the transition from competent to vegetative state in \textit{B. subtilis}. In addition, the effectiveness of the stochastic generalized cell mapping method is verified by Monte Carlo simulation.

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Cites work

• A Theory of Cell-to-Cell Mapping Dynamical Systems
• Cooperative differentiation through clustering in multicellular populations
• First-passage problem for strong nonlinear stochastic dynamical systems
• First-passage time of Duffing oscillator under combined harmonic and white-noise excitations
• Stochastic P-bifurcation and stochastic resonance in a noisy bistable fractional-order system
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Cited in

(2)

• Subtle interplay of stochasticity and deterministic dynamics pervades an evolutionary plausible genetic circuit for \textit{Bacillus subtilis} competence
• Point-cycle bistability and stochasticity in a regulatory circuit for \textit{Bacillus Subtilis} competence

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