Handling parameter variations during the treatment of type 1 diabetes mellitus: in silico results
Summary: Type 1 diabetic patients need a strict treatment to regulate blood glucose concentration in a target range. Despite the development of different control strategies, the model parameter variations, given by physiological changes, can generate an inaccurate treatment and in consequence hyperglycemia and hypoglycemia episodes. Therefore, it is necessary to use control techniques that compensate such effects and maintain the control goals. Here, the effect of parametric variations is examined by the sensitivity analysis from which the most influential parameters in glycemia dynamics are detected. Based on that, an offset-free MPC strategy for impulsive systems is given for the first time in literature and simulated for type 1 diabetes treatment. This scheme along with the impulsive zone MPC with artificial variables reestablishes the normoglycemia behavior since the parameter variations are adequately rejected. However, only parametric variations up to 50\% from their nominal values are well compensated, which suggests that more robust formulations are needed to ensure a greater rejection of physiological variations.
- Stable impulsive zone model predictive control for type \(1\) diabetic patients based on a long-term model
- Robust guaranteed-cost output feedback control of blood glucose in type \(1\) diabetes patient with intrapatient variability
- Optimal impulsive blood glucose control through multiple injections
- Adaptive fuzzy integral sliding mode control of blood glucose level in patients with type 1 diabetes: in silico studies
- Robust servo control of a novel type 1 diabetic model
- Control Strategies for Nonzero Set-Point Regulation of Linear Impulsive Systems
- Linear offset-free model predictive control
- Model Predictive Control for Linear Impulsive Systems
- Observability criteria for impulsive control systems with applications to biomedical engineering processes
- Predictive control with constraints
- Robust \(\mu\)-synthesis: towards a unified glucose control in adults, adolescents and children with T1DM
- Personalized mechanistic models for exercise, meal and insulin interventions in children and adolescents with type 1 diabetes
- Stable impulsive zone model predictive control for type \(1\) diabetic patients based on a long-term model
- Quantifying macrophage defects in type 1 diabetes
- Estimation of secondary effect parameters in glycaemic dynamics using accumulating data from a virtual type 1 diabetic patient
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