Oscillations in a white blood cell production model with multiple differentiation stages

DOI10.1007/S00285-019-01432-6zbMATH Open1440.34047arXiv1812.02017OpenAlexW2902863200WikidataQ90321978 ScholiaQ90321978MaRDI QIDQ2299258FDOQ2299258

Authors: Franziska Knauer, T. Stiehl, Anna Marciniak-Czochra 

Publication date: 21 February 2020

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model parameters. The Hopf bifurcation is a unique feature of the multi-compartment structure as it does not exist in the corresponding two-compartment model. It appears for a parameter set different from the parameters identified for healthy hematopoiesis and requires changes in at least two cell properties. Model analysis allows identifying a range of biologically plausible parameter sets that can explain persistent oscillations of white blood cell counts observed in some hematopoietic diseases. Relating the identified parameter sets to recent experimental and clinical findings provides insights into the pathological mechanisms leading to oscillating blood cell counts.

Full work available at URL: https://arxiv.org/abs/1812.02017

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zbMATH Keywords

Hopf bifurcationmathematical modelhematopoiesisstem cellsoscillating blood cell counts

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20) Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• Control of oscillations in hematopoiesis
• Oscillations in cyclical neutropenia: new evidence based on mathematical modeling
• A mathematical model of hematopoiesis. II: Cyclical neutropenia
• Elements of applied bifurcation theory
• Multistability in an age-structured model of hematopoiesis: cyclical neutropenia
• Characterization of stem cells using mathematical models of multistage cell lineages
• Mathematical modeling of leukemogenesis and cancer stem cell dynamics
• Global dynamics of two-compartment models for cell production systems with regulatory mechanisms
• Mass concentration in a nonlocal model of clonal selection
• Oscillations and global attractivity in models of hematopoiesis
• Observations on the pathophysiology and mechanisms for cyclic neutropenia
• Renormalization group second-order approximation for singularly perturbed nonlinear ordinary differential equations
• Mathematical models of oscillatory blood cell production

Cited In (10)

• A structured population model of clonal selection in acute leukemias with multiple maturation stages
• Hopf-bifurcation analysis of a stage-structured population model of cell differentiation
• Distributed delay differential equation representations of cyclic differential equations
• A Continuous Integral Model for White Blood Cell Production
• Dynamical properties of feedback signalling in B lymphopoiesis: a mathematical modelling approach
• Multiplicity of time scales in blood cell formation and leukemia
• Periodic oscillations in leukopoiesis models with two delays
• Mathematical analysis and global dynamics for a time-delayed chronic myeloid leukemia model with treatment
• Local asymptotic stability of a system of integro-differential equations describing clonal evolution of a self-renewing cell population under mutation
• Dynamics of competing heterogeneous clones in blood cancers explains multiple observations -- a mathematical modeling approach

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