Oscillations in a white blood cell production model with multiple differentiation stages
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Publication:2299258
Qualitative investigation and simulation of ordinary differential equation models (34C60) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20) Cell biology (92C37)
Abstract: In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model parameters. The Hopf bifurcation is a unique feature of the multi-compartment structure as it does not exist in the corresponding two-compartment model. It appears for a parameter set different from the parameters identified for healthy hematopoiesis and requires changes in at least two cell properties. Model analysis allows identifying a range of biologically plausible parameter sets that can explain persistent oscillations of white blood cell counts observed in some hematopoietic diseases. Relating the identified parameter sets to recent experimental and clinical findings provides insights into the pathological mechanisms leading to oscillating blood cell counts.
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Cites work
- scientific article; zbMATH DE number 699423 (Why is no real title available?)
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Cited in
(10)- Multiplicity of time scales in blood cell formation and leukemia
- Mathematical analysis and global dynamics for a time-delayed chronic myeloid leukemia model with treatment
- Dynamical properties of feedback signalling in B lymphopoiesis: a mathematical modelling approach
- Hopf-bifurcation analysis of a stage-structured population model of cell differentiation
- Distributed delay differential equation representations of cyclic differential equations
- Dynamics of competing heterogeneous clones in blood cancers explains multiple observations -- a mathematical modeling approach
- Periodic oscillations in leukopoiesis models with two delays
- A structured population model of clonal selection in acute leukemias with multiple maturation stages
- A Continuous Integral Model for White Blood Cell Production
- Local asymptotic stability of a system of integro-differential equations describing clonal evolution of a self-renewing cell population under mutation
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