Mass concentration in a nonlocal model of clonal selection
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Abstract: Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics of a continuum of cell clones structured by the self-renewal potential. The model is an extension of the finite multi-compartment models of interactions between normal and cancer cells in acute leukemias. It takes a form of a system of integro-differential equations with a nonlinear and nonlocal coupling, which describes regulatory feedback loops in cell proliferation and differentiation process. We show that such coupling leads to mass concentration in points corresponding to maximum of the self-renewal potential and the model solutions tend asymptotically to a linear combination of Dirac measures. Furthermore, using a Lyapunov function constructed for a finite dimensional counterpart of the model, we prove that the total mass of the solution converges to a globally stable equilibrium. Additionally, we show stability of the model in space of positive Radon measures equipped with flat metric. The analytical results are illustrated by numerical simulations.
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Cites work
- A nonlinear structured population model: Lipschitz continuity of measure-valued solutions with respect to model ingredients
- A structured population model of cell differentiation
- Analysis of particle methods for structured population models with nonlocal boundary term in the framework of bounded Lipschitz distance
- Characterization of stem cells using mathematical models of multistage cell lineages
- Concentration in Lotka-Volterra parabolic or integral equations: a general convergence result
- Dirac concentrations in Lotka-Volterra parabolic PDEs
- Dirac mass dynamics in multidimensional nonlocal parabolic equations
- Evolutionary game theory on measure spaces: well-posedness
- Global dynamics of two-compartment models for cell production systems with regulatory mechanisms
- scientific article; zbMATH DE number 3920139 (Why is no real title available?)
- scientific article; zbMATH DE number 3467467 (Why is no real title available?)
- scientific article; zbMATH DE number 1455131 (Why is no real title available?)
- scientific article; zbMATH DE number 1909499 (Why is no real title available?)
- scientific article; zbMATH DE number 1448982 (Why is no real title available?)
- Mathematical modeling of leukemogenesis and cancer stem cell dynamics
- Measure solutions for some models in population dynamics
- Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
- Multiparametric Bifurcation Analysis of a Basic Two-Stage Population Model
- On a problem with two-time data for the Vlasov equation
- On Choosing and Bounding Probability Metrics
- On selection dynamics for competitive interactions
- On selection dynamics for continuous structured populations
- On the -convergence of discrete dynamics and variational integrators
- Optimal Transport
- Optimization and nonsmooth analysis
- Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
- Rate distributions and survival of the fittest: a formulation on the space of measures
- Small mutation rate and evolutionarily stable strategies in infinite dimensional adaptive dynam\-ics
- Splitting-particle methods for structured population models: convergence and applications
- Stability analysis of multi-compartment models for cell production systems
- Stationary distributions under mutation-selection balance: structure and properties
- STATIONARY SOLUTIONS OF A SELECTION MUTATION MODEL: THE PURE MUTATION CASE
- Structured population equations in metric spaces
- Structured populations, cell growth and measure valued balance laws
- SURVIVAL OF THE FITTEST IN A GENERALIZED LOGISTIC MODEL
- Transport equations in biology.
Cited in
(18)- The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
- Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy
- Dynamics of concentration in a population model structured by age and a phenotypical trait
- Dynamics of concentration in a population structured by age and a phenotypic trait with mutations. Convergence of the corrector
- Discrete-time population dynamics on the state space of measures
- Local asymptotic stability of a system of integro-differential equations describing clonal evolution of a self-renewing cell population under mutation
- Modelling collective cell migration: neural crest as a model paradigm
- Oscillations in a white blood cell production model with multiple differentiation stages
- Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments
- A structured population model of clonal selection in acute leukemias with multiple maturation stages
- Mathematical analysis of a clonal evolution model of tumour cell proliferation
- Global stability with selection in integro-differential Lotka-Volterra systems modelling trait-structured populations
- Dynamical spike solutions in a nonlocal model of pattern formation
- Large time behavior and Lyapunov functionals for a nonlocal differential equation
- Asymptotic analysis of selection-mutation models in the presence of multiple fitness peaks
- Measure framework for the pure selection equation: global well posedness and numerical investigations
- Structured population models on Polish spaces: A unified approach including graphs, Riemannian manifolds and measure spaces to describe dynamics of heterogeneous populations
- Multiplicity of time scales in blood cell formation and leukemia
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