Mathematical analysis of a clonal evolution model of tumour cell proliferation

DOI10.1007/S00028-016-0369-8zbMATH Open1367.35187arXiv1511.05046OpenAlexW3124072694MaRDI QIDQ2397413FDOQ2397413

Authors: József Z. Farkas, Glenn Webb 

Publication date: 22 May 2017

Published in: Journal of Evolution Equations (Search for Journal in Brave)

Abstract: We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non-standard non-local boundary condition. We establish global existence of solutions and study their qualitative behaviour. We study the effect of telomere restoration on cancer cell dynamics. Our results indicate that without telomere restoration, the cell population extinguishes. With telomere restoration, exponential growth occurs in the linear model. We further characterise the specific growth behaviour of the cell population for special cases. We also study the effects of crowding induced mortality on the qualitative behaviour, and the existence and stability of steady states of a nonlinear model incorporating crowding effect. We present examples and extensive numerical simulations, which illustrate the rich dynamic behaviour of the linear and nonlinear models.

Full work available at URL: https://arxiv.org/abs/1511.05046

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zbMATH Keywords

asymptotic behavioursemigroups of operatorsstructured populationscancer modellingtelomere self-renewal

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

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Cited In (7)

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• The evolution of tumor metastases during clonal expansion
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• Age-structured delayed SIPCV epidemic model of HPV and cervical cancer cells dynamics I. Numerical method
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• Stability analysis of an age-structured model of cervical cancer cells and HPV dynamics
• A mathematical model for the evolution of cell populations under the action of mutagenic agents

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