Mathematical analysis of a clonal evolution model of tumour cell proliferation
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Publication:2397413
Abstract: We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non-standard non-local boundary condition. We establish global existence of solutions and study their qualitative behaviour. We study the effect of telomere restoration on cancer cell dynamics. Our results indicate that without telomere restoration, the cell population extinguishes. With telomere restoration, exponential growth occurs in the linear model. We further characterise the specific growth behaviour of the cell population for special cases. We also study the effects of crowding induced mortality on the qualitative behaviour, and the existence and stability of steady states of a nonlinear model incorporating crowding effect. We present examples and extensive numerical simulations, which illustrate the rich dynamic behaviour of the linear and nonlinear models.
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Cited in
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- A mathematical model for the evolution of cell populations under the action of mutagenic agents
- Qualitative analysis of a PDE model of telomere loss in a proliferating cell population in the light of suns and stars
- Mathematical and numerical analysis for a model of growing metastatic tumors
- Age-structured delayed SIPCV epidemic model of HPV and cervical cancer cells dynamics I. Numerical method
- The evolution of tumor metastases during clonal expansion
- Dynamics of competing heterogeneous clones in blood cancers explains multiple observations -- a mathematical modeling approach
- Stability analysis of an age-structured model of cervical cancer cells and HPV dynamics
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