Analysis of a mathematical model for the growth of cancer cells

DOI10.1093/IMAMMB/DQS019MaRDI QIDQ2840470zbMATH OpenOpenAlexWikidataFDO

Authors Martin Kohlmann

Publication date 18 July 2013

Published in Mathematical Medicine and Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1104.2442

zbMATH Keywords

stabilityfree boundary problemwell-posednesstumour growthflat stationary solutions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35)

Abstract: In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or cell dead. The growth process is caused by a diffusing nutrient concentration $sigma$ and is controlled by an internal cell pressure $p$. We assume that the tumor occupies a strip-like domain with a fixed boundary at $y=0$ and a free boundary $y=ho(x)$, where $ho$ is a $2pi$-periodic function. First, we prove the existence of solutions $(sigma,p,ho)$ and that the model allows for peculiar stationary solutions. As a main result we establish that these equilibrium points are locally asymptotically stable under small perturbations.

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Cited in

(9)

• scientific article; zbMATH DE number 6671632 (Why is no real title available?)
• A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer
• Mathematical analysis of a clonal evolution model of tumour cell proliferation
• Multiple solutions of a model describing cancerous growth
• Analysis of a mathematical model of the growth of necrotic tumors
• Modeling and analysis of a multilayer solid tumour with cell physiological age and resource limitations
• Asymptotic stability of constant steady states for a 2 2 reaction-diffusion system arising in cancer modelling
• A numerical analysis of a model of growth tumor
• Bifurcation Analysis in a Cancer Growth Model

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