Analysis of a mathematical model for the growth of cancer cells

DOI10.1093/IMAMMB/DQS019zbMATH Open1267.92044arXiv1104.2442OpenAlexW3104835361WikidataQ45327479 ScholiaQ45327479MaRDI QIDQ2840470FDOQ2840470

Authors: Martin Kohlmann 

Publication date: 18 July 2013

Published in: Mathematical Medicine and Biology (Search for Journal in Brave)

Abstract: In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or cell dead. The growth process is caused by a diffusing nutrient concentration $sigma$ and is controlled by an internal cell pressure $p$. We assume that the tumor occupies a strip-like domain with a fixed boundary at $y=0$ and a free boundary $y=ho(x)$, where $ho$ is a $2pi$-periodic function. First, we prove the existence of solutions $(sigma,p,ho)$ and that the model allows for peculiar stationary solutions. As a main result we establish that these equilibrium points are locally asymptotically stable under small perturbations.

Full work available at URL: https://arxiv.org/abs/1104.2442

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zbMATH Keywords

stabilityfree boundary problemwell-posednesstumour growthflat stationary solutions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35)

Cited In (9)

• Title not available (Why is that?)
• A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer
• Mathematical analysis of a clonal evolution model of tumour cell proliferation
• Analysis of a mathematical model of the growth of necrotic tumors
• Multiple solutions of a model describing cancerous growth
• Modeling and analysis of a multilayer solid tumour with cell physiological age and resource limitations
• Asymptotic stability of constant steady states for a \(2\times 2\) reaction-diffusion system arising in cancer modelling
• A numerical analysis of a model of growth tumor
• Bifurcation Analysis in a Cancer Growth Model

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