Investigation of solid tumor progression with account of proliferation/migration dichotomy via Darwinian mathematical model

DOI10.1007/S00285-019-01434-4MaRDI QIDQ2299259zbMATH OpenOpenAlexWikidataFDO

Authors M. B. Kuznetsov, A. V. Kolobov

Publication date 21 February 2020

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-019-01434-4

zbMATH Keywords

tumor progressionsolid tumor growthmathematical oncologytumor cell motilityintratumoral heterogeneityspatially distributed modeling

Mathematics Subject Classification ID

Problems related to evolution (92D15) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Integro-partial differential equations (35R09) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

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Cites work

• A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype
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• Analysis of anticancer efficiency of combined fractionated radiotherapy and antiangiogenic therapy via mathematical modelling
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• Angiogenesis and vascular remodelling in normal and cancerous tissues
• Flux-corrected transport. I: SHASTA, a fluid transport algorithm that works
• Individual-based and continuum models of growing cell populations: a comparison
• Mathematical modelling of chemotherapy combined with bevacizumab
• Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
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• New insights into vascular collapse and growth dynamics in solid tumors
• Numerical recipes. The art of scientific computing.
• Optimal response to chemotherapy for a mathematical model of tumor-immune dynamics
• Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
• The Role of Cell Motility in Metastatic Cell Dominance Phenomenon: Analysis by a Mathematical Model
• The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
• Transient alleviation of tumor hypoxia during first days of antiangiogenic therapy as a result of therapy-induced alterations in nutrient supply and tumor metabolism -- analysis by mathematical modeling

Cited in

(6)

• Evolution of cell motility in an individual-based model of tumour growth
• A phenotype-structured model to reproduce the avascular growth of a tumor and its interaction with the surrounding environment
• Short-range migration can alter evolutionary dynamics in solid tumors
• Optimization of antitumor radiotherapy fractionation via mathematical modeling with account of 4 R's of radiobiology
• Spatial stochastic models of cancer: fitness, migration, invasion
• Explicit separation of growth and motility in a new tumor cord model

Describes a project that uses

Uses Software

• SHASTA

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