Short-range migration can alter evolutionary dynamics in solid tumors

DOI10.1088/1742-5468/AB4983MaRDI QIDQ5149449zbMATH OpenOpenAlexWikidataFDO

Authors Youness Azimzade, Abbas Ali Saberi

Publication date 11 February 2021

Published in Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1909.11597

Mathematics Subject Classification ID

Medical applications (general) (92C50) Problems related to evolution (92D15) Computational methods for problems pertaining to biology (92-08)

Abstract: Here, we investigate how competition in the Eden model is affected by short range dispersal and the requirement that site updates occur only after several updates of the same site have been attempted previously. The latter models the effect of tissue or media resistance to invasion. We found that the existence of tissue intensifies 'Natural Selection' and de-accelerating 'Genetic Drift', both to a limited extent. More interestingly, our results show that short-range migration can eliminate Genetic demixing and conceal Natural Selection.

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Cites work

• scientific article; zbMATH DE number 3148873 (Why is no real title available?)
• Canonical orthonormal Wigner supermultiplet basis
• Evolution in range expansions with competition at rough boundaries
• Spatial Moran models I. stochastic tunneling in the neutral case
• Spatial stochastic models for cancer initiation and progression
• The importance of being discrete (and spatial)

Cited in

(1)

• The evolution of tumor metastases during clonal expansion

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