Short-range migration can alter evolutionary dynamics in solid tumors

DOI10.1088/1742-5468/AB4983zbMATH Open1456.92077arXiv1909.11597OpenAlexW2981467223WikidataQ107968279 ScholiaQ107968279MaRDI QIDQ5149449FDOQ5149449

Authors: Youness Azimzade, Abbas Ali Saberi 

Publication date: 11 February 2021

Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Abstract: Here, we investigate how competition in the Eden model is affected by short range dispersal and the requirement that site updates occur only after several updates of the same site have been attempted previously. The latter models the effect of tissue or media resistance to invasion. We found that the existence of tissue intensifies 'Natural Selection' and de-accelerating 'Genetic Drift', both to a limited extent. More interestingly, our results show that short-range migration can eliminate Genetic demixing and conceal Natural Selection.

Full work available at URL: https://arxiv.org/abs/1909.11597

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Mathematics Subject Classification ID

Medical applications (general) (92C50) Problems related to evolution (92D15) Computational methods for problems pertaining to biology (92-08)

Cites Work

• The importance of being discrete (and spatial)
• Spatial Moran models I. stochastic tunneling in the neutral case
• Spatial stochastic models for cancer initiation and progression
• Title not available (Why is that?)
• Canonical orthonormal Wigner supermultiplet basis
• Evolution in range expansions with competition at rough boundaries

Cited In (1)

• The evolution of tumor metastases during clonal expansion

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