Direct computation of two-phase icosahedral equilibria of lipid bilayer vesicles

DOI10.1016/J.CMA.2016.07.011zbMATH Open1439.74166arXiv1606.05827OpenAlexW2464046843MaRDI QIDQ2310366FDOQ2310366

Qingdu Li, Timothy J. Healey, Siming Zhao

Publication date: 6 April 2020

Published in: Computer Methods in Applied Mechanics and Engineering (Search for Journal in Brave)

Abstract: Correctly formulated continuum models for lipid-bilayer membranes present a significant challenge to computational mechanics. In particular, the mid-surface behavior is that of a 2-dimensional fluid, while the membrane resists bending much like an elastic shell. Here we consider a well-known Helfrich-Cahn-Hilliard model for two-phase lipid-bilayer vesicles, incorporating mid-surface fluidity, curvature elasticity and a phase field. We present a systematic approach to the direct computation of vesical configurations possessing icosahedral symmetry, which have been observed in experiment and whose mathematical existence has recently been established. We first introduce a radial-graph formulation to overcome the difficulties associated with fluidity within a conventional Lagrangian description. We use the so-called subdivision surface finite element method combined with an icosahedral-symmetric mesh. The resulting discrete equations are well-conditioned and inherit equivariance properties under a representation of the icosahedral group. We use group-theoretic methods to obtain a reduced problem that captures all icosahedral-symmetric solutions of the full problem. Finally we explore the behavior of our reduced model, varying numerous physical parameters present in the mathematical model.

Full work available at URL: https://arxiv.org/abs/1606.05827

zbMATH Keywords

numerical continuationsymmetry reductionmembrane mechanicssubdivision surface finite element

Mathematics Subject Classification ID

Physiology (general) (92C30) Fluid-solid interactions (including aero- and hydro-elasticity, porosity, etc.) (74F10) Physiological flows (76Z05) Membranes (74K15)

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Cited In (4)

• A gauge-fixing procedure for spherical fluid membranes and application to computations
• Computational modeling of coupled interactions of fluid membranes with embedded filaments
• Numerical methods for biomembranes: Conforming subdivision methods versus non-conforming PL methods
• Symmetry-Breaking Global Bifurcation in a Surface Continuum Phase-Field Model for Lipid Bilayer Vesicles

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