Optimal control for cancer chemotherapy under tumor heterogeneity with Michealis-Menten pharmacodynamics

DOI10.3934/dcdsb.2019100zbMath1418.92063WikidataQ128061457 ScholiaQ128061457MaRDI QIDQ2316404

Shuo Wang, Heinz Schättler

Publication date: 26 July 2019

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/dcdsb.2019100

zbMATH Keywords

optimal control; pharmacodynamics; Michaelis-Menten kinetics; tumor heterogeneity; ensemble systems

Mathematics Subject Classification ID

49K20: Optimality conditions for problems involving partial differential equations

92C45: Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)

92C50: Medical applications (general)