The invasion speed of cell migration models with realistic cell cycle time distributions

DOI10.1016/J.JTBI.2018.09.010zbMATH Open1422.92022arXiv1806.03140OpenAlexW2962991244WikidataQ91466495 ScholiaQ91466495MaRDI QIDQ2328239FDOQ2328239

Authors: Enrico Gavagnin, Matthew J. Ford, Richard L. Mort, Tim Rogers, Christian A. Yates 

Publication date: 10 October 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this assumption is often far from the real cell cycle time distribution (CCTD). Recent studies have suggested an alternative approach to modelling cell proliferation based on a multi-stage representation of the CCTD. In order to validate and parametrise these models, it is important to connect them to experimentally measurable quantities. In this paper we investigate the connection between the CCTD and the speed of the collective invasion. We first state a result for a general CCTD, which allows the computation of the invasion speed using the Laplace transform of the CCTD. We use this to deduce the range of speeds for the general case. We then focus on the more realistic case of multi-stage models, using both a stochastic agent-based model and a set of reaction-diffusion equations for the cells' average density. By studying the corresponding travelling wave solutions, we obtain an analytical expression for the speed of invasion for a general N-stage model with identical transition rates, in which case the resulting cell cycle times are Erlang distributed. We show that, for a general N-stage model, the Erlang distribution and the exponential distribution lead to the minimum and maximum invasion speed, respectively. This result allows us to determine the range of possible invasion speeds in terms of the average proliferation time for any multi-stage model.

Full work available at URL: https://arxiv.org/abs/1806.03140

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zbMATH Keywords

cell migrationtravelling waveagent-based modelmulti-stage modelinvasion speedcell cycle time distribution

Mathematics Subject Classification ID

Traveling wave solutions (35C07) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17)

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Cited In (6)

• Age structure can account for delayed logistic proliferation of scratch assays
• Invasion fronts and adaptive dynamics in a model for the growth of cell populations with heterogeneous mobility
• On characterization of the exponential distribution via hypoexponential distributions
• Velocity-jump processes with proliferation
• Effects of delay in a biological environment subject to tumor dynamics
• A novel mathematical model of heterogeneous cell proliferation

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