Accounting for tube hematocrit in modeling of blood flow in cerebral capillary networks

DOI10.1155/2019/4235937MaRDI QIDQ2332549zbMATH OpenOpenAlexWikidataFDO

Authors Andrey Egorovich Kovtanyuk, I. N. Sidorenko, Renée Lampe, Nikolai D. Botkin, Varvara L. Turova

Publication date 4 November 2019

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2019/4235937

zbMATH Keywords

blood flow modelingcerebral capillary networkstube hematocrit level

Mathematics Subject Classification ID

Physiological flow (92C35)

Review text

Summary: The aim of this paper consists in the derivation of an analytic formula for the hydraulic resistance of capillaries, taking into account the tube hematocrit level. The consistency of the derived formula is verified using finite element simulations. Such an effective formula allows for assigning resistances, depending on the hematocrit level, to the edges of networks modeling biological capillary systems, which extends our earlier models of blood flow through large capillary networks. Numerical simulations conducted for large capillary networks with random topologies demonstrate the importance of accounting for the hematocrit level for obtaining consistent results.

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Cites work

• Blood flow in the microcirculation
• scientific article; zbMATH DE number 1067607 (Why is no real title available?)
• scientific article; zbMATH DE number 2063296 (Why is no real title available?)
• Mathematical modelling of cerebral blood circulation and cerebral autoregulation: towards preventing intracranial hemorrhages in preterm newborns
• New development in freefem++
• Red blood cell distribution in simplified capillary networks

Cited in

(8)

• A computational model of hemodynamic parameters in cortical capillary networks
• Mathematical modeling of cerebral capillary blood flow heterogeneity and its effect on brain tissue oxygen levels
• A mathematical model for blood flow accounting for the hematological disorders
• Modeling the pressure distribution in a spatially averaged cerebral capillary network
• Red blood cell distribution in simplified capillary networks
• On boundary permeation through the walls of blocked cerebral capillaries: a non-linear model
• Analysis and prediction of hematocrit in microvascular networks
• Multi-scale homogenization of blood flow in 3-dimensional human cerebral microvascular networks

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Uses Software

• FreeFem++

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