Dynamics of bone cell interactions and differential responses to PTH and antibody-based therapies

DOI10.1007/S11538-018-0533-0MaRDI QIDQ2334400zbMATH OpenOpenAlexWikidataFDO

Authors V. Lemaire, D. R. Cox

Publication date 7 November 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-018-0533-0

zbMATH Keywords

bone remodelingcombination therapiesdenosumab (anti-RANKL antibody)intermittent PTHmathematical modelingosteoporosispharmacokinetics of monoclonal antibodiesromosozumab (anti-sclerostin antibody)Wnt pathway

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Dynamics of bone cell signaling and PTH treatments of osteoporosis
• Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
• Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling

Cited in

(10)

• Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling
• Effects of prolactin on bone remodeling process with parathyroid hormone supplement: an impulsive mathematical model
• An impulsive mathematical model of bone formation and resorption: effects of parathyroid hormone, calcitonin and impulsive estrogen supplement
• Nonlinear modeling and control strategies for bone diseases based on TGF\(\beta\) and Wnt factors
• Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
• What can mathematics do for drug development?
• Computational model of the dual action of PTH -- application to a rat model of osteoporosis
• Model-based analysis of IGF-1 effect on osteoblast and osteoclast regulation in bone turnover
• Dynamics of bone cell signaling and PTH treatments of osteoporosis
• Development of a computational modelling platform for patient-specific treatment of osteoporosis

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