The Cellular Dynamics of Bone Remodeling: A Mathematical Model
From MaRDI portal
Abstract: The mechanical properties of vertebrate bone are largely determined by a process which involves the complex interplay of three different cell types. This process is called {it bone remodeling}, and occurs asynchronously at multiple sites in the mature skeleton. The cells involved are bone resorbing osteoclasts, bone matrix producing osteoblasts and mechanosensing osteocytes. These cells communicate with each other by means of autocrine and paracrine signaling factors and operate in complex entities, the so-called bone multicellular units (BMU). To investigate the BMU dynamics in silico, we develop a novel mathematical model resulting in a system of nonlinear partial differential equations with time delays. The model describes the osteoblast and osteoclast populations together with the dynamics of the key messenger molecule RANKL and its decoy receptor OPG. Scaling theory is used to address parameter sensitivity and predict the emergence of pathological remodeling regimes. The model is studied numerically in one and two space dimensions using finite difference schemes in space and explicit delay equation solvers in time. The computational results are in agreement with in vivo observations and provide new insights into the role of the RANKL/OPG pathway in the spatial regulation of bone remodeling.
Recommendations
- A model for bone mechanics and remodeling including cell populations dynamics
- A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus
- scientific article; zbMATH DE number 2097718
- A mathematical model of bone remodeling with delays
- scientific article; zbMATH DE number 2097735
- Analysis of a bone remodeling model
- Mathematical model of bone remodeling captures the antiresorptive and anabolic actions of various therapies
- Modelling the anabolic response of bone using a cell population model
- Approximation of bone remodeling models
- On a class of bone cell-based remodeling laws with spatial fading influence of stimuli
Cited in
(44)- Mathematical approaches to bone reformation phenomena and numerical simulations
- Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling
- Simplifying biochemical tumorous bone remodeling models through variable order derivatives
- A model for bone mechanics and remodeling including cell populations dynamics
- A mathematical model of cartilage regeneration after cell therapy
- Influence of non-isotropy of osseous tissues and cross-sectional non- uniformity of a long bone on the internal remodelling dynamics of osseous tissues
- A model for the change of cancellous bone volume and structure over time
- Towards a new spatial representation of bone remodeling
- Modeling of the kinetics of vitamin \(\text{D}_3\) in osteoblastic cells
- Nonlinear modeling and control strategies for bone diseases based on TGF\(\beta\) and Wnt factors
- A mathematical model for bone cell population dynamics of fracture healing considering the effect of energy dissipation
- Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
- Dynamics of self-excited generators with diverse nonlinear delayed feedbacks
- Normal and quasinormal forms for systems of difference and differential-difference equations
- Dynamic modeling of bone remodeling, osteolytic metastasis and PK/PD therapy: introducing variable order derivatives as a simplification technique
- Antigen receptor therapy in bone metastasis via optimal control for different human life stages
- Dynamics of bone cell interactions and differential responses to PTH and antibody-based therapies
- Mathematical model of bone remodeling captures the antiresorptive and anabolic actions of various therapies
- Bone remodeling as a spatial evolutionary game
- Osteocytes as a record of bone formation dynamics: a mathematical model of osteocyte generation in bone matrix
- Modelling the anabolic response of bone using a cell population model
- Dynamic modeling of bone metastasis, microenvironment and therapy, Integrating parathyroid hormone (PTH) effect, anti-resorptive and anti-cancer therapy
- A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus
- A mathematical model for the growth of elongated bones
- Coupling systems biology with multiscale mechanics, for computer simulations of bone remodeling
- A coupled mechano-biochemical model for bone adaptation
- scientific article; zbMATH DE number 2097718 (Why is no real title available?)
- A mathematical model of bone remodeling with delays
- Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress
- Stability analysis of a Komarova type model for the interactions of osteoblast and osteoclast cells during bone remodeling
- Simultaneous multi-parametric analysis of bone cell population model
- A new model of bone remodeling and turnover set up in the framework of generalized continuum mechanics
- A Combined Process Algebraic and Stochastic Approach to Bone Remodeling
- A cellular automata model of bone formation
- Dynamics of a system for migration from proliferative to dormant status
- A novel mathematical model for growth of capillaries and nutrient supply with application to prediction of osteophyte onset
- Understanding the fundamental molecular mechanism of osteogenic differentiation from mesenchymal stem cells
- Bone Formation: Biological Aspects and Modelling Problems
- A p‐adaptive, implicit‐explicit mixed finite element method for diffusion‐reaction problems
- Modelling the effects of growth and remodelling on the density and structure of cancellous bone
- Part II: A new perspective for modeling the bone remodeling process: biology, mechanics, and pathologies
- A mathematical model for fibrous dysplasia: the role of the flow of mutant cells
- Analytic approach to explore dynamical osteoporotic bone turnover
- Primal-mixed formulations for reaction-diffusion systems on deforming domains
This page was built for publication: The Cellular Dynamics of Bone Remodeling: A Mathematical Model
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3068615)
