An invitation to pharmacostatics

DOI10.1007/S11538-017-0369-ZMaRDI QIDQ2334403zbMATH OpenOpenAlexWikidataFDO

Authors Gilles Ph. Gnacadja

Publication date 7 November 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-017-0369-z

zbMATH Keywords

fixed-point algorithmpolynomial system solvingequilibrium calculationnon-monotone dose-response curvepharmacostaticsreceptor pharmacology

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Solving polynomial systems; resultants (13P15)

Recommendations

• Topics in mathematical pharmacology
• Pharmacokinetics: ODE and statistical model choice
• Population Pharmacokinetic/Pharmacodynamic Methodology and Applications: A Bibliography
• Mathematics of pharmacokinetics and pharmacodynamics: diversity of topics, models and methods
• Statistical Modeling of a Pharmacokinetic System
• Drugs in the classroom: using pharmacokinetics to introduce biomathematical modeling
• Dose-response in pharmacokinetics

Cites work

• A method to calculate binding equilibrium concentrations in the allosteric ternary complex model that supports ligand depletion
• Fixed points of order-reversing maps in ℝn>0 and chemical equilibrium
• Implicit dose-response curves
• Monotonicity of interleukin-1 receptor-ligand binding with respect to antagonist in the presence of decoy receptor
• Univalent positive polynomial maps and the equilibrium state of chemical networks of reversible binding reactions

Cited in

(3)

• Challenges in pharmacology modelling
• Algebraic study of receptor-ligand systems: a dose-response analysis
• What can mathematics do for drug development?

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