Algebraic study of receptor-ligand systems: a dose-response analysis

DOI10.1137/22M1506262MaRDI QIDQ6597814zbMATH OpenFDO

Authors Léa Sta, Michael F. Adamer, Carmen Molina-París

Publication date 4 September 2024

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1137/22M1506262

zbMATH Keywords

amplitudecellular fatecytokinedose-responseGröbner basishalf-maximal effective concentrationkinasereceptorsignalingsteady state

Mathematics Subject Classification ID

Gröbner bases; other bases for ideals and modules (e.g., Janet and border bases) (13P10) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Algebraic systems biology: a case study for the Wnt pathway
• Comprehensive Gröbner bases
• Gröbner bases for polynomial systems with parameters
• Gröbner bases of reaction networks with intermediate species
• How far is complex balancing from detailed balancing?
• Implicit dose-response curves
• Mathematical models for immunology: current state of the art and future research directions
• Multistationarity in structured reaction networks
• Parallel algorithms for Gröbner-basis construction
• Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach
• The topological proof of Abel-Ruffini theorem

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