Optimal treatment strategies for HIV with antibody response

DOI10.1155/2014/685289MaRDI QIDQ2336636zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 19 November 2019

Published in Journal of Applied Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 3.0 Unported

Full work available at URL https://doi.org/10.1155/2014/685289

Mathematics Subject Classification ID

Optimality conditions for problems involving ordinary differential equations (49K15) Applications of optimal control and differential games (49N90) Medical applications (general) (92C50)

Review text

Summary: Numerical analysis and optimization tools are used to suggest improved therapies to try and cure HIV infection. An HIV model of ordinary differential equation, which includes immune response, neutralizing antibodies, and multidrug effects, is improved. For a fixed time, single-drug and two-drug treatment strategies are explored based on Pontryagin's maximum principle. Using different combinations of weight factor pairs combining with special upper-bound pairs for controls, nine types of treatment policies are determined and different therapy effects are numerically simulated with a gradient projection method. Some strategies are effective, but some strategies are not particularly helpful for the therapy of HIV/AIDS. Comparing the effective treatment strategies, we find a more appropriate strategy with maximizing the number of uninfected CD\(4^+\)T-cells and minimizing the number of active virus.

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Cited in

(4)

• An optimal scheme to boost immunity and suppress viruses for HIV by combining a phased immunotherapy with the sustaining antiviral therapy
• An optimal strategy for HIV multitherapy
• Optimal controls of the highly active antiretroviral therapy
• Optimal timing of antiviral therapy in HIV infection

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