Costs versus benefits: best possible and best practical treatment regimens for HIV

DOI10.1007/S00285-006-0059-1MaRDI QIDQ2373250zbMATH OpenOpenAlexWikidataFDO

Authors Olga Krakovska, Lindi M. Wahl

Publication date 17 July 2007

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-006-0059-1

zbMATH Keywords

Drug treatmentHAARTHuman immunodeficiency virusMathematical modelOptimizationResistanceSide effects

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

• A model for treatment strategy in the chemotherapy of AIDS
• Dynamic multidrug therapies for HIV: Optimal and STI control approaches
• HIV dynamics: Modeling, data analysis, and optimal treatment protocols
• scientific article; zbMATH DE number 1247361 (Why is no real title available?)
• scientific article; zbMATH DE number 1262329 (Why is no real title available?)
• scientific article; zbMATH DE number 2038872 (Why is no real title available?)
• Optimal control of an HIV immunology model
• Optimal control of the chemotherapy of HIV
• Optimal HIV treatment by maximising immune response
• Predicting differential responses to structured treatment interruptions during HAART
• Stochastic optimal therapy for enhanced immune response

Cited in

(13)

• Combinatorial optimization in rapidly mutating drug-resistant viruses
• Explicitly accounting for antiretroviral drug uptake in theoretical HIV models predicts long-term failure of protease-only therapy
• Optimal drug treatment regimens for HIV depend on adherence
• Drug-sparing regimens for HIV combination therapy: Benefits predicted for ``drug coasting
• Optimal therapy regimens for treatment-resistent mutations of HIV
• Kinetic model of HIV infection including hematopoietic progenitor cells
• Mathematical analysis of an HIV model with impulsive antiretroviral drug doses
• Treatment monitoring of HIV-infected patients based on mechanistic models
• The evaluation and prediction model of the effect of AIDS therapy
• A model incorporating combined RTIs and PIs therapy during early HIV-1 infection
• Optimal control of HIV dynamic using embedding method
• Multiobjective optimal control of HIV dynamics
• Analysis of HIV therapy in the liver using optimal control and pharmacokinetics

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