A fully resolved active musculo-mechanical model for esophageal transport

DOI10.1016/J.JCP.2015.05.049zbMATH Open1349.76939DBLPjournals/jcphy/KouBGPKP15arXiv1501.02010OpenAlexW1556640377WikidataQ35854573 ScholiaQ35854573MaRDI QIDQ2374656FDOQ2374656

Peter J. Kahrilas, John E. Pandolfino, Neelesh A. Patankar, Amneet Pal Singh Bhalla, Wenjun Kou, Boyce E. Griffith

Publication date: 5 December 2016

Published in: Journal of Computational Physics (Search for Journal in Brave)

Abstract: Esophageal transport is a physiological process that mechanically transports an ingested food bolus from the pharynx to the stomach via the esophagus, a multi-layered muscular tube. This process involves interactions between the bolus, the esophagus, and the neurally coordinated activation of the esophageal muscles. In this work, we use an immersed boundary (IB) approach to simulate peristaltic transport in the esophagus. The bolus is treated as a viscous fluid that is actively transported by the muscular esophagus, which is modeled as an actively contracting, fiber-reinforced tube. A simplified version of our model is verified by comparison to an analytic solution to the tube dilation problem. Three different complex models of the multi-layered esophagus, which differ in their activation patterns and the layouts of the mucosal layers, are then extensively tested. To our knowledge, these simulations are the first of their kind to incorporate the bolus, the multi-layered esophagus tube, and muscle activation into an integrated model. Consistent with experimental observations, our simulations capture the pressure peak generated by the muscle activation pulse that travels along the bolus tail. These fully resolved simulations provide new insights into roles of the mucosal layers during bolus transport. In addition, the information on pressure and the kinematics of the esophageal wall due to the coordination of muscle activation is provided, which may help relate clinical data from manometry and ultrasound images to the underlying esophageal motor function.

Full work available at URL: https://arxiv.org/abs/1501.02010

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zbMATH Keywords

fluid-structure interactionimmersed boundary methodmuscle activationesophageal transport

Mathematics Subject Classification ID

Fluid-solid interactions (including aero- and hydro-elasticity, porosity, etc.) (74F10) Physiological flows (76Z05) Biomechanics (92C10)

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Cited In (10)

• A flow-reconstruction based approach for the computation of hydrodynamic stresses on immersed body surface
• Handling Neumann and Robin boundary conditions in a fictitious domain volume penalization framework
• An immersed interface method for discrete surfaces
• A mathematical model for oesophageal swallowing of a food-bolus
• The smooth forcing extension method: a high-order technique for solving elliptic equations on complex domains
• Peristaltic transport of a particulate suspension in the small intestine
• Stencil penalty approach based constraint immersed boundary method
• On the Lagrangian-Eulerian coupling in the immersed finite element/difference method
• Mechanics of the stomach: A review of an emerging field of biomechanics
• An immersed peridynamics model of fluid-structure interaction accounting for material damage and failure

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