Force-driven growth of intercellular junctions

DOI10.1016/J.JTBI.2017.03.028MaRDI QIDQ2404010zbMATH OpenOpenAlexWikidataFDO

Authors Mohammad Tehrani, Alireza S. Sarvestani

Publication date 12 September 2017

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1710.03325

zbMATH Keywords

Gibbs free energygrowthmechanotransduction

Mathematics Subject Classification ID

Biophysics (92C05) Cell biology (92C37) Biochemistry, molecular biology (92C40)

Abstract: Mechanical force regulates the formation and growth of cell-cell junctions. Cadherin is a prominent homotypic cell adhesion molecule that plays a crucial role in establishment of intercellular adhesion. It is known that the transmitted force through the cadherin-mediated junctions directly correlates with the growth and enlargement of the junctions. In this paper, we propose a physical model for the structural evolution of cell-cell junctions subjected to pulling tractions, using the Bell-Dembo-Bongard thermodynamic model. Cadherins have multiple adhesive states and may establish slip or catch bonds depending on the Ca 2+ concentration. We conducted a comparative study between the force-dependent behavior of clusters of slip and catch bonds. The results show that the clusters of catch bonds feature some hallmarks of cell mechanotransduction in response to the pulling traction. This is a passive thermodynamic response and is entirely controlled by the effect of mechanical work of the pulling force on the free energy landscape of the junction.

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Cited in

(3)

• A mathematical model of -catenin dimerization at adherens junctions in polarized epithelial cells
• Nonlinear mechanical modeling of cell adhesion
• Cell adhesion as dynamic interplay of lock-and-key, generic and elastic forces

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