The role of topology and mechanics in uniaxially growing cell networks

DOI10.1098/RSPA.2019.0523zbMATH Open1472.92111arXiv1904.11161OpenAlexW2999433334WikidataQ89819547 ScholiaQ89819547MaRDI QIDQ5160852FDOQ5160852

Authors: Alexander Erlich, Gareth Wyn Jones, Françoise Tisseur, D. E. Moulton, Alain Goriely 

Publication date: 29 October 2021

Published in: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Abstract: In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or strain-driven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth.

Full work available at URL: https://arxiv.org/abs/1904.11161

Recommendations

• Are homeostatic states stable? Dynamical stability in morphoelasticity
• A dynamic cellular vertex model of growing epithelial tissues
• Modeling growth in biological materials
• A theoretical model for tissue growth in confined geometries
• scientific article; zbMATH DE number 1961359

zbMATH Keywords

self-organizationbiomechanicsnetwork structurecell mechanicsbiological tissuesgrowth modelling

Mathematics Subject Classification ID

Systems biology, networks (92C42) Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis
• Perspectives on biological growth and remodeling
• A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening
• Stress-Modulated Growth
• The mathematics and mechanics of biological growth
• Discrete calculus. Applied analysis on graphs for computational science
• Morpho-elastodynamics: the long-time dynamics of elastic growth
• Title not available (Why is that?)
• An energy-deformation decomposition for morphoelasticity
• How to characterize a nonlinear elastic material? A review on nonlinear constitutive parameters in isotropic finite elasticity
• Mechanobiological stability of biological soft tissues
• Force networks, torque balance and airy stress in the planar vertex model of a confluent epithelium
• Are homeostatic states stable? Dynamical stability in morphoelasticity

Cited In (6)

• Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations
• Mechanism creation in tensegrity structures by cellular morphogenesis
• Stability bounds of a delay visco-elastic rheological model with substrate friction
• THE USE OF FARADAY INSTABILITY TO PRODUCE DEFINED TOPOLOGICAL ORGANIZATION IN CULTURES OF MAMMALIAN CELLS
• Force-driven growth of intercellular junctions
• On the role of physics in the growth and pattern formation of multi-cellular systems: what can we learn from individual-cell based models?

This page was built for publication: The role of topology and mechanics in uniaxially growing cell networks

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5160852)