The role of topology and mechanics in uniaxially growing cell networks

DOI10.1098/RSPA.2019.0523MaRDI QIDQ5160852zbMATH OpenOpenAlexWikidataFDO

Authors Alexander Erlich, Gareth Wyn Jones, Françoise Tisseur, D. E. Moulton, Alain Goriely

Publication date 29 October 2021

Published in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1904.11161, https://www.research.manchester.ac.uk/portal/en/publications/the-role-of-topology-and-mechanics-in-uniaxially-growing-cell-networks(4a5ab9a4-b3a3-47bf-8ef9-efa34025255e).html

zbMATH Keywords

self-organizationbiomechanicsnetwork structurecell mechanicsbiological tissuesgrowth modelling

Mathematics Subject Classification ID

Systems biology, networks (92C42) Cell biology (92C37)

Abstract: In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or strain-driven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth.

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Cited in

(6)

• Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations
• Mechanism creation in tensegrity structures by cellular morphogenesis
• Stability bounds of a delay visco-elastic rheological model with substrate friction
• THE USE OF FARADAY INSTABILITY TO PRODUCE DEFINED TOPOLOGICAL ORGANIZATION IN CULTURES OF MAMMALIAN CELLS
• Force-driven growth of intercellular junctions
• On the role of physics in the growth and pattern formation of multi-cellular systems: what can we learn from individual-cell based models?

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